Pathogenesis of experimental Leptospira interrogans serotype icterohaemorrhagiae infection in the guinea pigs: possible role of endotoxin of intestinal bacteria in the development of lesions.

Robert Higgins, J. P. Descôteaux, R. Degré

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Germ-free guinea pigs were infected with a virulent strain of Leptospira interrogans serotype icterohaemorrhagiae to evaluate the possible role of endotoxin of intestinal bacteria in the development of hemorrhages and hepatic and renal failure. Clinical manifestations, necropsy findings and histological lesions were similar to those seen in control animals. In the second part of the experiment, endotoxin was not detected by the Limulus test in the blood of ten guinea pigs during the five day course of leptospirosis.

Original languageEnglish (US)
Pages (from-to)304-308
Number of pages5
JournalCanadian Journal of Comparative Medicine
Volume44
Issue number3
StatePublished - Jul 1 1980
Externally publishedYes

ASJC Scopus subject areas

  • veterinary(all)

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