Pathogenesis of experimental Leptospira interrogans serotype icterohaemorrhagiae infection in the guinea pigs

possible role of endotoxin of intestinal bacteria in the development of lesions.

Robert Higgins, J. P. Descôteaux, R. Degré

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Germ-free guinea pigs were infected with a virulent strain of Leptospira interrogans serotype icterohaemorrhagiae to evaluate the possible role of endotoxin of intestinal bacteria in the development of hemorrhages and hepatic and renal failure. Clinical manifestations, necropsy findings and histological lesions were similar to those seen in control animals. In the second part of the experiment, endotoxin was not detected by the Limulus test in the blood of ten guinea pigs during the five day course of leptospirosis.

Original languageEnglish (US)
Pages (from-to)304-308
Number of pages5
JournalCanadian Journal of Comparative Medicine
Volume44
Issue number3
StatePublished - Jul 1 1980
Externally publishedYes

Fingerprint

Leptospira interrogans
endotoxins
intestinal microorganisms
Endotoxins
lesions (animal)
guinea pigs
Guinea Pigs
serotypes
Limulus Test
pathogenesis
Bacteria
Limulus
liver failure
Leptospirosis
hematologic tests
leptospirosis
Liver Failure
renal failure
Infection
infection

ASJC Scopus subject areas

  • veterinary(all)

Cite this

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abstract = "Germ-free guinea pigs were infected with a virulent strain of Leptospira interrogans serotype icterohaemorrhagiae to evaluate the possible role of endotoxin of intestinal bacteria in the development of hemorrhages and hepatic and renal failure. Clinical manifestations, necropsy findings and histological lesions were similar to those seen in control animals. In the second part of the experiment, endotoxin was not detected by the Limulus test in the blood of ten guinea pigs during the five day course of leptospirosis.",
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AU - Degré, R.

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