Germ-free guinea pigs were infected with a virulent strain of Leptospira interrogans serotype icterohaemorrhagiae to evaluate the possible role of endotoxin of intestinal bacteria in the development of hemorrhages and hepatic and renal failure. Clinical manifestations, necropsy findings and histological lesions were similar to those seen in control animals. In the second part of the experiment, endotoxin was not detected by the Limulus test in the blood of ten guinea pigs during the five day course of leptospirosis.
|Original language||English (US)|
|Number of pages||5|
|Journal||Canadian Journal of Comparative Medicine|
|State||Published - Jul 1 1980|
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