Pathogenesis of Bronchiectasis

Research output: Contribution to journalArticlepeer-review

56 Scopus citations


Cystic fibrosis (CF) typically follows a more severe clinical course than non-CF bronchiectasis. Despite this recognized difference, the underpinnings of respiratory biology support a common pathogeneses of the anatomic deformations of bronchiectasis. This article reviews the observed manifestations among the related diseases of bronchiectasis and CF and discusses some of their similarities and differences. As more details of the mechanisms of bronchiectasis are unveiled, more parallels among the seemingly disparate causes of CF and non-CF bronchiectasis are recognized. With these insights, more opportunities to halt the vicious circle have become apparent.

Original languageEnglish (US)
Pages (from-to)289-296
Number of pages8
JournalClinics in Chest Medicine
Issue number2
StatePublished - Jun 2007

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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