Pathogen-specific risk of chronic gastrointestinal disorders following bacterial causes of foodborne illness

Chad K. Porter, Daniel Choi, Brooks Cash, Mark Pimentel, Joseph Murray, Larissa S May, Mark S. Riddle

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Background: The US CDC estimates over 2 million foodborne illnesses are annually caused by 4 major enteropathogens: non-typhoid Salmonella spp., Campylobacter spp., Shigella spp. and Yersinia enterocoltica. While data suggest a number of costly and morbid chronic sequelae associated with these infections, pathogen-specific risk estimates are lacking. We utilized a US Department of Defense medical encounter database to evaluate the risk of several gastrointestinal disorders following select foodborne infections.Methods: We identified subjects with acute gastroenteritis between 1998 to 2009 attributed to Salmonella (nontyphoidal) spp., Shigella spp., Campylobacter spp. or Yersinia enterocolitica and matched each with up to 4 unexposed subjects. Medical history was analyzed for the duration of military service time (or a minimum of 1 year) to assess for incident chronic gastrointestinal disorders. Relative risks were calculated using modified Poisson regression while controlling for the effect of covariates.Results: A total of 1,753 pathogen-specific gastroenteritis cases (Campylobacter: 738, Salmonella: 624, Shigella: 376, Yersinia: 17) were identified and followed for a median of 3.8 years. The incidence (per 100,000 person-years) of PI sequelae among exposed was as follows: irritable bowel syndrome (IBS), 3.0; dyspepsia, 1.8; constipation, 3.9; gastroesophageal reflux disease (GERD), 9.7. In multivariate analyses, we found pathogen-specific increased risk of IBS, dyspepsia, constipation and GERD.Conclusions: These data confirm previous studies demonstrating risk of chronic gastrointestinal sequelae following bacterial enteric infections and highlight additional preventable burden of disease which may inform better food security policies and practices, and prompt further research into pathogenic mechanisms.

Original languageEnglish (US)
Article number46
JournalBMC Gastroenterology
Volume13
Issue number1
DOIs
StatePublished - Mar 8 2013
Externally publishedYes

Fingerprint

Foodborne Diseases
Shigella
Campylobacter
Salmonella
Yersinia
Irritable Bowel Syndrome
Dyspepsia
Gastroenteritis
Constipation
Gastroesophageal Reflux
United States Department of Defense
Nutrition Policy
Yersinia enterocolitica
Food Supply
Centers for Disease Control and Prevention (U.S.)
Infection
Bacterial Infections
Multivariate Analysis
Databases
Incidence

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Pathogen-specific risk of chronic gastrointestinal disorders following bacterial causes of foodborne illness. / Porter, Chad K.; Choi, Daniel; Cash, Brooks; Pimentel, Mark; Murray, Joseph; May, Larissa S; Riddle, Mark S.

In: BMC Gastroenterology, Vol. 13, No. 1, 46, 08.03.2013.

Research output: Contribution to journalArticle

Porter, Chad K. ; Choi, Daniel ; Cash, Brooks ; Pimentel, Mark ; Murray, Joseph ; May, Larissa S ; Riddle, Mark S. / Pathogen-specific risk of chronic gastrointestinal disorders following bacterial causes of foodborne illness. In: BMC Gastroenterology. 2013 ; Vol. 13, No. 1.
@article{9242eabc162a4c0b9f8231502645364e,
title = "Pathogen-specific risk of chronic gastrointestinal disorders following bacterial causes of foodborne illness",
abstract = "Background: The US CDC estimates over 2 million foodborne illnesses are annually caused by 4 major enteropathogens: non-typhoid Salmonella spp., Campylobacter spp., Shigella spp. and Yersinia enterocoltica. While data suggest a number of costly and morbid chronic sequelae associated with these infections, pathogen-specific risk estimates are lacking. We utilized a US Department of Defense medical encounter database to evaluate the risk of several gastrointestinal disorders following select foodborne infections.Methods: We identified subjects with acute gastroenteritis between 1998 to 2009 attributed to Salmonella (nontyphoidal) spp., Shigella spp., Campylobacter spp. or Yersinia enterocolitica and matched each with up to 4 unexposed subjects. Medical history was analyzed for the duration of military service time (or a minimum of 1 year) to assess for incident chronic gastrointestinal disorders. Relative risks were calculated using modified Poisson regression while controlling for the effect of covariates.Results: A total of 1,753 pathogen-specific gastroenteritis cases (Campylobacter: 738, Salmonella: 624, Shigella: 376, Yersinia: 17) were identified and followed for a median of 3.8 years. The incidence (per 100,000 person-years) of PI sequelae among exposed was as follows: irritable bowel syndrome (IBS), 3.0; dyspepsia, 1.8; constipation, 3.9; gastroesophageal reflux disease (GERD), 9.7. In multivariate analyses, we found pathogen-specific increased risk of IBS, dyspepsia, constipation and GERD.Conclusions: These data confirm previous studies demonstrating risk of chronic gastrointestinal sequelae following bacterial enteric infections and highlight additional preventable burden of disease which may inform better food security policies and practices, and prompt further research into pathogenic mechanisms.",
author = "Porter, {Chad K.} and Daniel Choi and Brooks Cash and Mark Pimentel and Joseph Murray and May, {Larissa S} and Riddle, {Mark S.}",
year = "2013",
month = "3",
day = "8",
doi = "10.1186/1471-230X-13-46",
language = "English (US)",
volume = "13",
journal = "BMC Gastroenterology",
issn = "1471-230X",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Pathogen-specific risk of chronic gastrointestinal disorders following bacterial causes of foodborne illness

AU - Porter, Chad K.

AU - Choi, Daniel

AU - Cash, Brooks

AU - Pimentel, Mark

AU - Murray, Joseph

AU - May, Larissa S

AU - Riddle, Mark S.

PY - 2013/3/8

Y1 - 2013/3/8

N2 - Background: The US CDC estimates over 2 million foodborne illnesses are annually caused by 4 major enteropathogens: non-typhoid Salmonella spp., Campylobacter spp., Shigella spp. and Yersinia enterocoltica. While data suggest a number of costly and morbid chronic sequelae associated with these infections, pathogen-specific risk estimates are lacking. We utilized a US Department of Defense medical encounter database to evaluate the risk of several gastrointestinal disorders following select foodborne infections.Methods: We identified subjects with acute gastroenteritis between 1998 to 2009 attributed to Salmonella (nontyphoidal) spp., Shigella spp., Campylobacter spp. or Yersinia enterocolitica and matched each with up to 4 unexposed subjects. Medical history was analyzed for the duration of military service time (or a minimum of 1 year) to assess for incident chronic gastrointestinal disorders. Relative risks were calculated using modified Poisson regression while controlling for the effect of covariates.Results: A total of 1,753 pathogen-specific gastroenteritis cases (Campylobacter: 738, Salmonella: 624, Shigella: 376, Yersinia: 17) were identified and followed for a median of 3.8 years. The incidence (per 100,000 person-years) of PI sequelae among exposed was as follows: irritable bowel syndrome (IBS), 3.0; dyspepsia, 1.8; constipation, 3.9; gastroesophageal reflux disease (GERD), 9.7. In multivariate analyses, we found pathogen-specific increased risk of IBS, dyspepsia, constipation and GERD.Conclusions: These data confirm previous studies demonstrating risk of chronic gastrointestinal sequelae following bacterial enteric infections and highlight additional preventable burden of disease which may inform better food security policies and practices, and prompt further research into pathogenic mechanisms.

AB - Background: The US CDC estimates over 2 million foodborne illnesses are annually caused by 4 major enteropathogens: non-typhoid Salmonella spp., Campylobacter spp., Shigella spp. and Yersinia enterocoltica. While data suggest a number of costly and morbid chronic sequelae associated with these infections, pathogen-specific risk estimates are lacking. We utilized a US Department of Defense medical encounter database to evaluate the risk of several gastrointestinal disorders following select foodborne infections.Methods: We identified subjects with acute gastroenteritis between 1998 to 2009 attributed to Salmonella (nontyphoidal) spp., Shigella spp., Campylobacter spp. or Yersinia enterocolitica and matched each with up to 4 unexposed subjects. Medical history was analyzed for the duration of military service time (or a minimum of 1 year) to assess for incident chronic gastrointestinal disorders. Relative risks were calculated using modified Poisson regression while controlling for the effect of covariates.Results: A total of 1,753 pathogen-specific gastroenteritis cases (Campylobacter: 738, Salmonella: 624, Shigella: 376, Yersinia: 17) were identified and followed for a median of 3.8 years. The incidence (per 100,000 person-years) of PI sequelae among exposed was as follows: irritable bowel syndrome (IBS), 3.0; dyspepsia, 1.8; constipation, 3.9; gastroesophageal reflux disease (GERD), 9.7. In multivariate analyses, we found pathogen-specific increased risk of IBS, dyspepsia, constipation and GERD.Conclusions: These data confirm previous studies demonstrating risk of chronic gastrointestinal sequelae following bacterial enteric infections and highlight additional preventable burden of disease which may inform better food security policies and practices, and prompt further research into pathogenic mechanisms.

UR - http://www.scopus.com/inward/record.url?scp=84874689311&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84874689311&partnerID=8YFLogxK

U2 - 10.1186/1471-230X-13-46

DO - 10.1186/1471-230X-13-46

M3 - Article

C2 - 23510245

AN - SCOPUS:84874689311

VL - 13

JO - BMC Gastroenterology

JF - BMC Gastroenterology

SN - 1471-230X

IS - 1

M1 - 46

ER -