Passive transfer of sera with antivirus neutralizing activity from adult channel catfish protects juveniles from channel catfish virus disease

Ronald Hedrick, T. McDowell

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Juvenile channel catfish Ictalurus punctatus were found to be protected from experimental infections of channel catfish virus (CCV) after passive transfer of adult sera with anti-CCV neutralizing activity. Juveniles in control groups that received injections of normal serum or saline and were then challenged with CCV experienced average cumulative mortalities of 66 and 71%, respectively. In contrast, juveniles receiving serum with anti-CCV activity (neutralization index of 102.6) via intraperitoneal injections had an average cumulative mortality of 1%. Furthermore, fish in the control groups showed typical signs of channel catfish virus disease and contained virus concentrations of up to 107TCID50 (50% tissue culture infective dose endpoint) per gram of tissue. In comparison, no signs of disease were observed among fish receiving serum containing anti-CCV neutralizing activity. These studies demonstrated that serum with anti-CCV neutralizing activity (presumably due to anti-CCV antibody) obtained from adult channel catfish can protect juveniles from lethal challenges with CCV. However, the role of antivirus antibodies in recovery from primary infections and in virus expression during latent infections remains unknown.

Original languageEnglish (US)
Pages (from-to)277-281
Number of pages5
JournalTransactions of the American Fisheries Society
Volume116
Issue number2
DOIs
StatePublished - Jan 1 1987

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Ictalurid herpesvirus 1
Ictalurus punctatus
neutralization
serum
virus
antibody
infection
viruses
antibodies
mortality
intraperitoneal injection
endpoints
fish
tissue culture

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Aquatic Science

Cite this

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title = "Passive transfer of sera with antivirus neutralizing activity from adult channel catfish protects juveniles from channel catfish virus disease",
abstract = "Juvenile channel catfish Ictalurus punctatus were found to be protected from experimental infections of channel catfish virus (CCV) after passive transfer of adult sera with anti-CCV neutralizing activity. Juveniles in control groups that received injections of normal serum or saline and were then challenged with CCV experienced average cumulative mortalities of 66 and 71{\%}, respectively. In contrast, juveniles receiving serum with anti-CCV activity (neutralization index of 102.6) via intraperitoneal injections had an average cumulative mortality of 1{\%}. Furthermore, fish in the control groups showed typical signs of channel catfish virus disease and contained virus concentrations of up to 107TCID50 (50{\%} tissue culture infective dose endpoint) per gram of tissue. In comparison, no signs of disease were observed among fish receiving serum containing anti-CCV neutralizing activity. These studies demonstrated that serum with anti-CCV neutralizing activity (presumably due to anti-CCV antibody) obtained from adult channel catfish can protect juveniles from lethal challenges with CCV. However, the role of antivirus antibodies in recovery from primary infections and in virus expression during latent infections remains unknown.",
author = "Ronald Hedrick and T. McDowell",
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AU - McDowell, T.

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N2 - Juvenile channel catfish Ictalurus punctatus were found to be protected from experimental infections of channel catfish virus (CCV) after passive transfer of adult sera with anti-CCV neutralizing activity. Juveniles in control groups that received injections of normal serum or saline and were then challenged with CCV experienced average cumulative mortalities of 66 and 71%, respectively. In contrast, juveniles receiving serum with anti-CCV activity (neutralization index of 102.6) via intraperitoneal injections had an average cumulative mortality of 1%. Furthermore, fish in the control groups showed typical signs of channel catfish virus disease and contained virus concentrations of up to 107TCID50 (50% tissue culture infective dose endpoint) per gram of tissue. In comparison, no signs of disease were observed among fish receiving serum containing anti-CCV neutralizing activity. These studies demonstrated that serum with anti-CCV neutralizing activity (presumably due to anti-CCV antibody) obtained from adult channel catfish can protect juveniles from lethal challenges with CCV. However, the role of antivirus antibodies in recovery from primary infections and in virus expression during latent infections remains unknown.

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