Passive Smoke Effects on Cough and Airways in Young Guinea Pigs: Role of Brainstem Substance P

Jesse P. Joad, Paul A. Munch, John M. Bric, Samuel J. Evans, Kent E. Pinkerton, Chao Yin Chen, Ann C. Bonham

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Children raised with extended exposure to environmental tobacco smoke (ETS) experience increased cough and wheeze. This study was designed to determine whether extended ETS exposure enhances citric acid-induced cough and bronchoconstriction in young guinea pigs via a neurokinin-1 (NK-1) receptor mechanism at the first central synapse of lung afferent neurons, the nucleus tractus solitarlus. Guinea pigs were exposed to ETS from 1 to 6 weeks of age. At 5 weeks of age, guide cannulae were implanted bilaterally in the medial nucleus tractus solitarius at a site that produced apnea in response to the glutamate agonist D,L-homocysteic acid. At 6 weeks of age, either vehicle or a NK-1 receptor antagonist, SR 140333, was injected into the nucleus tractus solitarius of the conscious guinea pigs who were then exposed to citric acid aerosol. ETS exposure significantly enhanced citric acid-induced cough by 56% and maximal Penh (a measure of airway obstruction) by 43%, effects that were attenuated by the NK-1 receptor antagonist In the nucleus tractus solitarius. We conclude that in young guinea pigs extended exposure to ETS increases citric acid-induced cough and broncho-constriction in part by an NK-1 receptor mechanism in the nucleus tractus solitarius.

Original languageEnglish (US)
Pages (from-to)499-504
Number of pages6
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume169
Issue number4
StatePublished - Feb 15 2004

Fingerprint

Substance P
Cough
Solitary Nucleus
Smoke
Brain Stem
Tobacco
Guinea Pigs
Citric Acid
Neurokinin-1 Receptor Antagonists
Neurokinin-1 Receptors
Environmental Exposure
Excitatory Amino Acid Agonists
Afferent Neurons
Bronchoconstriction
Apnea
Airway Obstruction
Aerosols
Constriction
Synapses
Lung

Keywords

  • Development
  • Environmental tobacco smoke
  • Guinea pig
  • Nucleus tractus solitarius
  • Substance P

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Passive Smoke Effects on Cough and Airways in Young Guinea Pigs : Role of Brainstem Substance P. / Joad, Jesse P.; Munch, Paul A.; Bric, John M.; Evans, Samuel J.; Pinkerton, Kent E.; Chen, Chao Yin; Bonham, Ann C.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 169, No. 4, 15.02.2004, p. 499-504.

Research output: Contribution to journalArticle

Joad, Jesse P. ; Munch, Paul A. ; Bric, John M. ; Evans, Samuel J. ; Pinkerton, Kent E. ; Chen, Chao Yin ; Bonham, Ann C. / Passive Smoke Effects on Cough and Airways in Young Guinea Pigs : Role of Brainstem Substance P. In: American Journal of Respiratory and Critical Care Medicine. 2004 ; Vol. 169, No. 4. pp. 499-504.
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