Passive immunization of newborn rhesus macaques prevents oral simian immunodeficiency virus infection

Koen K A Van Rompay, Christopher J. Berardi, Stephan Dillard-Telm, Ross P. Tarara, Don R. Canfield, Celia R. Valverde, David C. Montefiori, Kelly Stefano Cole, Ronald C. Montelaro, Christopher J. Miller, Marta L. Marthas

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Abstract

To determine if passively acquired antiviral antibodies modulate virus transmission and disease progression in human pediatric AIDS, the potential of pre- and postexposure passive immunization with hyperimmune serum to prevent oral simian immunodeficiency virus (SIV) infection or disease progression in newborn rhesus macaques was tested. Untreated neonates became infected after oral SIV inoculation and had high viremia, and most animals developed fatal AIDS within 3 months. In contrast, SIV hyperimmune serum given subcutaneously prior to oral SIV inoculation protected 6 newborns against infection. When this SIV hyperimmune serum was given to 3 newborns 3 weeks after oral SIV inoculation, viremia was not reduced, and all 3 infants died within 3 months of age due to AIDS and immune-complex disease. These results suggest that passively acquired antihuman immunodeficiency virus (HIV) IgG may decrease perinatal HIV transmission. However, anti-HIV Ig(3 may not impart therapeutic benefit to infants with estahushed HIV infection.

Original languageEnglish (US)
Pages (from-to)1247-1259
Number of pages13
JournalJournal of Infectious Diseases
Volume177
Issue number5
StatePublished - 1998

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ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Van Rompay, K. K. A., Berardi, C. J., Dillard-Telm, S., Tarara, R. P., Canfield, D. R., Valverde, C. R., Montefiori, D. C., Cole, K. S., Montelaro, R. C., Miller, C. J., & Marthas, M. L. (1998). Passive immunization of newborn rhesus macaques prevents oral simian immunodeficiency virus infection. Journal of Infectious Diseases, 177(5), 1247-1259.