TY - JOUR
T1 - Passive immunization of newborn rhesus macaques prevents oral simian immunodeficiency virus infection
AU - Van Rompay, Koen K A
AU - Berardi, Christopher J.
AU - Dillard-Telm, Stephan
AU - Tarara, Ross P.
AU - Canfield, Don R.
AU - Valverde, Celia R.
AU - Montefiori, David C.
AU - Cole, Kelly Stefano
AU - Montelaro, Ronald C.
AU - Miller, Christopher J.
AU - Marthas, Marta L.
PY - 1998
Y1 - 1998
N2 - To determine if passively acquired antiviral antibodies modulate virus transmission and disease progression in human pediatric AIDS, the potential of pre- and postexposure passive immunization with hyperimmune serum to prevent oral simian immunodeficiency virus (SIV) infection or disease progression in newborn rhesus macaques was tested. Untreated neonates became infected after oral SIV inoculation and had high viremia, and most animals developed fatal AIDS within 3 months. In contrast, SIV hyperimmune serum given subcutaneously prior to oral SIV inoculation protected 6 newborns against infection. When this SIV hyperimmune serum was given to 3 newborns 3 weeks after oral SIV inoculation, viremia was not reduced, and all 3 infants died within 3 months of age due to AIDS and immune-complex disease. These results suggest that passively acquired antihuman immunodeficiency virus (HIV) IgG may decrease perinatal HIV transmission. However, anti-HIV Ig(3 may not impart therapeutic benefit to infants with estahushed HIV infection.
AB - To determine if passively acquired antiviral antibodies modulate virus transmission and disease progression in human pediatric AIDS, the potential of pre- and postexposure passive immunization with hyperimmune serum to prevent oral simian immunodeficiency virus (SIV) infection or disease progression in newborn rhesus macaques was tested. Untreated neonates became infected after oral SIV inoculation and had high viremia, and most animals developed fatal AIDS within 3 months. In contrast, SIV hyperimmune serum given subcutaneously prior to oral SIV inoculation protected 6 newborns against infection. When this SIV hyperimmune serum was given to 3 newborns 3 weeks after oral SIV inoculation, viremia was not reduced, and all 3 infants died within 3 months of age due to AIDS and immune-complex disease. These results suggest that passively acquired antihuman immunodeficiency virus (HIV) IgG may decrease perinatal HIV transmission. However, anti-HIV Ig(3 may not impart therapeutic benefit to infants with estahushed HIV infection.
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M3 - Article
C2 - 9593009
AN - SCOPUS:17344370858
VL - 177
SP - 1247
EP - 1259
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 5
ER -