PASSCLAIM - Diet-related cardiovascular disease

Ronald P. Mensink, Antti Aro, Elly Den Hond, J. Bruce German, Bruce A. Griffin, Hans Ulrich Ter Meer, Marja Mutanen, Daphne Pannemans, Wilhelm Stahl

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Cardiovascular disease (CVD) has a multifactorial aetiology and many potential risk markers are known. As it was not feasible to discuss all markers and their possible interactions in relation to all aspects of CVD, selections had to be made in this paper. In the context of claims and functional foods, emphasis was placed on those aetiological processes and risk markers that have been shown previously to be modified by diet: lipid and lipoprotein metabolism, haemostatic function, oxidative damage, homocysteine metabolism, and blood pressure. Except for methodological and biological characteristics of these biomarkers, their relationships with the risk of CVD are discussed. For LDL and HDL cholesterol, fasting triacylglycerol, homocysteine, and blood pressure well-validated, easy applicable, and generally accepted biomarkers exist. For haemostatic function and oxidative damage validation of markers with respect to CVD or intermediate clinical markers is recommended. For diet-related CVD, however, the ultimate question is whether changes in the biomarker are truly related to changes in risk. Only for LDL cholesterol and blood pressure does consensus exist among scientists for a possible application as enhanced function claims. For HDL, triacylglycerol, and homocysteine, and in particular for haemostatic function and oxidative damage, however, formal proof is lacking that diet-induced changes in these biomarkers alter the risk of CVD. At the same time, it should be emphasised that CVD is multifactorial. Therefore it does not seem justified that a change in one particular biomarker is enough evidence to substantiate a claim. There are examples of food components or drugs that one biomarker is changed in a favourable way, but at the same time another biomarker is changed in an unfavourable way. Therefore, studies to further validate generic predictors for the CVD risk should be initiated.

Original languageEnglish (US)
JournalEuropean Journal of Nutrition
Volume42
Issue numberSUPPL. 1
DOIs
StatePublished - 2003

Fingerprint

cardiovascular diseases
Cardiovascular Diseases
Biomarkers
biomarkers
Diet
diet
homocysteine
Homocysteine
Hemostatics
blood pressure
Blood Pressure
low density lipoprotein cholesterol
LDL Cholesterol
Triglycerides
risk factors
triacylglycerols
Functional Food
metabolism
Lipid Metabolism
high density lipoprotein cholesterol

Keywords

  • Blood pressure
  • Cholesterol
  • Claims cardiovascular disease
  • Diet
  • HDL cholesterol hemostasis
  • Homocysteine
  • Oxidation
  • Triacylglycerol

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Mensink, R. P., Aro, A., Hond, E. D., German, J. B., Griffin, B. A., Ter Meer, H. U., ... Stahl, W. (2003). PASSCLAIM - Diet-related cardiovascular disease. European Journal of Nutrition, 42(SUPPL. 1). https://doi.org/10.1007/s00394-003-1102-2

PASSCLAIM - Diet-related cardiovascular disease. / Mensink, Ronald P.; Aro, Antti; Hond, Elly Den; German, J. Bruce; Griffin, Bruce A.; Ter Meer, Hans Ulrich; Mutanen, Marja; Pannemans, Daphne; Stahl, Wilhelm.

In: European Journal of Nutrition, Vol. 42, No. SUPPL. 1, 2003.

Research output: Contribution to journalArticle

Mensink, RP, Aro, A, Hond, ED, German, JB, Griffin, BA, Ter Meer, HU, Mutanen, M, Pannemans, D & Stahl, W 2003, 'PASSCLAIM - Diet-related cardiovascular disease', European Journal of Nutrition, vol. 42, no. SUPPL. 1. https://doi.org/10.1007/s00394-003-1102-2
Mensink RP, Aro A, Hond ED, German JB, Griffin BA, Ter Meer HU et al. PASSCLAIM - Diet-related cardiovascular disease. European Journal of Nutrition. 2003;42(SUPPL. 1). https://doi.org/10.1007/s00394-003-1102-2
Mensink, Ronald P. ; Aro, Antti ; Hond, Elly Den ; German, J. Bruce ; Griffin, Bruce A. ; Ter Meer, Hans Ulrich ; Mutanen, Marja ; Pannemans, Daphne ; Stahl, Wilhelm. / PASSCLAIM - Diet-related cardiovascular disease. In: European Journal of Nutrition. 2003 ; Vol. 42, No. SUPPL. 1.
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