Parvalbumin in the monkey striate cortex: a quantitative immunoelectron-microscopy study

I. Blümcke, P. R. Hof, John Morrison, M. R. Celio

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

Parvalbumin (PV) is present in a subpopulation of interneurons in the visual cortex2, and also in thalamic afferents to the neocortex of primates18. The object of this study is to confirm by immunoelectron-microscopy the presence of intrinsic and extrinsic connections containing parvalbumin in the monkey visual cortex, by the demonstration of parvalbumin-immunoreactivity in symmetric and asymmetric synapses. We analyzed the distribution of parvalbumin-immunoreactive profiles at the ultrastructural level in the primary visual cortex of old world monkeys (Macaca fascicularis). It has been shown by others that parvalbumin-immunoreactive cells resemble non-spiny stellate cells, double-bouquet cells, chandelier and basket cells2,8,16,21. These neurons are known to be inhibitory and to form symmetric synapses. In fact, we observed that the vast majority of parvalbumin-immunoreactive synaptic contacts in the primary visual cortex of Macaca fascicularis are of the symmetric type (81.7%). Since parvalbumin-positive asymmetric contacts are also present (18.3%) and occur mostly in the thalamic recipient layers, 4C and 4A (9.9%), these afferents probably derive from parvalbumin-immunoreactive neurons located in the dorsal lateral geniculate nucleus of the thalamus.

Original languageEnglish (US)
Pages (from-to)237-243
Number of pages7
JournalBrain Research
Volume554
Issue number1-2
DOIs
StatePublished - Jul 19 1991
Externally publishedYes

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Keywords

  • Immunoelectron-microscopy
  • Monkey visual cortex
  • Parvalbumin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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