Parvalbumin-immunoreactive neurons in the neocortex are resistant to degeneration in alzheimer’s disease

Patrick R. Hof, Kevin Cox, Warren G. Young, Marco R. Celio, Joseph Rogers, John Morrison

Research output: Contribution to journalArticle

150 Scopus citations

Abstract

Recent studies have stressed the fact that specific neuronal subtypes may display a differential sensitivity to degeneration in Alzheimer’s disease. For example, large pyramidal neurons have been shown to be vulnerable, whereas smaller neurons are resistant to pathology. Using a monoclonal antibody against the calcium-binding protein parvalbumin, we investigated the possible changes in a subpopulation of intemeurons in two cortical areas known to be strongly damaged in Alzheimer’s disease. In the prefrontal cortex as well as in the inferior temporal cortex, we observed no differences in parvalbumin-immunoreactive cell counts or cell size in Alzheimer’s disease brains as compared to control cases. Moreover, the general cellular morphology of these neurons was preserved in the Alzheimer’s disease cases, in that their perikarya and dendritic arborizations were intact. These results suggest that parval- bumin-immunoreactive cells represent a neuronal subset resistant to degeneration, and further support the hypothesis that the pathological process in Alzheimer’s disease involves specific neuronal subtypes with particular morphological and molecular characteristics.

Original languageEnglish (US)
Pages (from-to)451-462
Number of pages12
JournalJournal of Neuropathology and Experimental Neurology
Volume50
Issue number4
DOIs
StatePublished - Jan 1 1991
Externally publishedYes

Keywords

  • Alzheimer’s disease
  • Calcium-binding proteins
  • Intemeurons
  • Neocortex, human
  • Quantitative neuroanatomy
  • γ-aminobutyric acid

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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