TY - JOUR
T1 - Parvalbumin-containing interneurons in rat hippocampus have an AMPA receptor profile suggestive of vulnerability to excitotoxicity
AU - Moga, Diana
AU - Hof, Patrick R.
AU - Vissavajjhala, Prabhakar
AU - Moran, Thomas M.
AU - Morrison, John
PY - 2002/6/19
Y1 - 2002/6/19
N2 - α-Amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors mediate excitatory neurotransmission in the central nervous system, and contain combinations of four subunits (GluR1-4). We developed a GluR3-specific monoclonal antibody and quantified the cellular distribution of GluR3 in rat hippocampus. GluR3 immunoreactivity was detected in all pyramidal neurons and most interneurons. In addition, we found a subset of parvalbumin (PV)-containing interneurons in the hippocampus and neocortex that was notable for its intense GluR3 immunoreactivity and lack of GluR2 immunoreactivity. Such an expression pattern of AMPA receptor subunits is likely to make these interneurons selectively vulnerable to excitotoxicity.
AB - α-Amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors mediate excitatory neurotransmission in the central nervous system, and contain combinations of four subunits (GluR1-4). We developed a GluR3-specific monoclonal antibody and quantified the cellular distribution of GluR3 in rat hippocampus. GluR3 immunoreactivity was detected in all pyramidal neurons and most interneurons. In addition, we found a subset of parvalbumin (PV)-containing interneurons in the hippocampus and neocortex that was notable for its intense GluR3 immunoreactivity and lack of GluR2 immunoreactivity. Such an expression pattern of AMPA receptor subunits is likely to make these interneurons selectively vulnerable to excitotoxicity.
KW - Excitatory amino acids
KW - GluR3
KW - Interneurons
UR - http://www.scopus.com/inward/record.url?scp=0036277760&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036277760&partnerID=8YFLogxK
U2 - 10.1016/S0891-0618(02)00012-1
DO - 10.1016/S0891-0618(02)00012-1
M3 - Article
C2 - 12048108
AN - SCOPUS:0036277760
VL - 23
SP - 249
EP - 253
JO - Journal of Chemical Neuroanatomy
JF - Journal of Chemical Neuroanatomy
SN - 0891-0618
IS - 4
ER -