Parvalbumin-containing interneurons in rat hippocampus have an AMPA receptor profile suggestive of vulnerability to excitotoxicity

Diana Moga, Patrick R. Hof, Prabhakar Vissavajjhala, Thomas M. Moran, John Morrison

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

α-Amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors mediate excitatory neurotransmission in the central nervous system, and contain combinations of four subunits (GluR1-4). We developed a GluR3-specific monoclonal antibody and quantified the cellular distribution of GluR3 in rat hippocampus. GluR3 immunoreactivity was detected in all pyramidal neurons and most interneurons. In addition, we found a subset of parvalbumin (PV)-containing interneurons in the hippocampus and neocortex that was notable for its intense GluR3 immunoreactivity and lack of GluR2 immunoreactivity. Such an expression pattern of AMPA receptor subunits is likely to make these interneurons selectively vulnerable to excitotoxicity.

Original languageEnglish (US)
Pages (from-to)249-253
Number of pages5
JournalJournal of Chemical Neuroanatomy
Volume23
Issue number4
DOIs
StatePublished - Jun 19 2002
Externally publishedYes

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Parvalbumins
AMPA Receptors
Interneurons
Hippocampus
Isoxazoles
Pyramidal Cells
Neocortex
Synaptic Transmission
Central Nervous System
Monoclonal Antibodies

Keywords

  • Excitatory amino acids
  • GluR3
  • Interneurons

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

Cite this

Parvalbumin-containing interneurons in rat hippocampus have an AMPA receptor profile suggestive of vulnerability to excitotoxicity. / Moga, Diana; Hof, Patrick R.; Vissavajjhala, Prabhakar; Moran, Thomas M.; Morrison, John.

In: Journal of Chemical Neuroanatomy, Vol. 23, No. 4, 19.06.2002, p. 249-253.

Research output: Contribution to journalArticle

Moga, Diana ; Hof, Patrick R. ; Vissavajjhala, Prabhakar ; Moran, Thomas M. ; Morrison, John. / Parvalbumin-containing interneurons in rat hippocampus have an AMPA receptor profile suggestive of vulnerability to excitotoxicity. In: Journal of Chemical Neuroanatomy. 2002 ; Vol. 23, No. 4. pp. 249-253.
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