Particles and microfluidics merged: Perspectives of highly sensitive diagnostic detection

Tania Konry, Shyam Sundhar Bale, Abhinav Bhushan, Keyue Shen, Erkin Seker, Boris Polyak, Martin Yarmush

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

There is a growing need for diagnostic technologies that provide laboratories with solutions that improve quality, enhance laboratory system productivity, and provide accurate detection of a broad range of infectious diseases and cancers. Recent advances in micro- and nanoscience and engineering, in particular in the areas of particles and microfluidic technologies, have advanced the "lab-on-a-chip" concept towards the development of a new generation of point-of-care diagnostic devices that could significantly enhance test sensitivity and speed. In this review, we will discuss many of the recent advances in microfluidics and particle technologies with an eye towards merging these two technologies for application in medical diagnostics. Although the potential diagnostic applications are virtually unlimited, the most important applications are foreseen in the areas of biomarker research, cancer diagnosis, and detection of infectious microorganisms.

Original languageEnglish (US)
Pages (from-to)251-269
Number of pages19
JournalMicrochimica Acta
Volume176
Issue number3-4
DOIs
StatePublished - Feb 2012

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Keywords

  • Bead based diagnostics
  • Biomarker research
  • Cancer diagnosis
  • Detection of infectious microorganisms
  • Diagnostic detection
  • Microfluidic
  • Particle technologies

ASJC Scopus subject areas

  • Analytical Chemistry

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