Parental tobacco and alcohol use and risk of hepatoblastoma in offspring: A report from the children's oncology group

Kimberly J. Johnson, Katherine S. Williams, Julie A. Ross, Mark D. Krailo, Gail E. Tomlinson, Marcio Malogolowkin, James H. Feusner, Logan G. Spector

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Hepatoblastoma is a rare pediatric liver tumor that has significantly increased in incidence over the last several decades. The International Agency for Research on Cancer (IARC) recently classified hepatoblastoma as a tobacco-related cancer. Parental alcohol use has shown no association. We examined associations between parental tobacco and alcohol use around the time of pregnancy and hepatoblastoma in a large case-control study. Methods: Maternal interviews were completed for 383 cases diagnosed in the United States during 2000- 2008. Controls (n = 387) were identified through U.S. birth registries and frequency-matched to cases on birth weight, birth year, and region of residence. We used unconditional logistic regression to calculate ORs and 95% confidence intervals (CI) for associations between parental smoking and maternal drinking and offspring hepatoblastoma. Results: We found no association between hepatoblastoma and maternal smoking at any time (OR, 1.0; 95% CI, 0.7-1.4), within the year before pregnancy (OR, 1.1; 95% CI, 0.8-1.6), early in pregnancy (OR, 1.0; 95% CI, 0.7-1.6), or throughout pregnancy (OR, 0.9; 95% CI, 0.5-1.6). We observed marginally positive associations between hepatoblastoma and paternal smoking in the year before pregnancy (OR, 1.4; 95% CI, 1.0-2.0) and during pregnancy (OR, 1.4; 95% CI, 0.9-2.0). Maternal alcohol use was not associated with hepatoblastoma. Conclusion: Our results do not provide evidence for an etiologic relationship between maternal smoking or drinking and hepatoblastoma, and only weak evidence for an association for paternal smoking in the year before pregnancy. Impact: Our study provides limited support for hepatoblastoma as a tobacco-related cancer; however, it remains wise to counsel prospective parents on the merits of smoking cessation.

Original languageEnglish (US)
Pages (from-to)1837-1843
Number of pages7
JournalCancer Epidemiology Biomarkers and Prevention
Volume22
Issue number10
DOIs
StatePublished - Oct 1 2013
Externally publishedYes

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Hepatoblastoma
Tobacco Use
Alcohols
Confidence Intervals
Pregnancy
Smoking
Mothers
Drinking
Tobacco
Neoplasms
Parturition
International Agencies
Smoking Cessation
Birth Weight
Registries
Case-Control Studies
Logistic Models
Interviews
Pediatrics

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Parental tobacco and alcohol use and risk of hepatoblastoma in offspring : A report from the children's oncology group. / Johnson, Kimberly J.; Williams, Katherine S.; Ross, Julie A.; Krailo, Mark D.; Tomlinson, Gail E.; Malogolowkin, Marcio; Feusner, James H.; Spector, Logan G.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 22, No. 10, 01.10.2013, p. 1837-1843.

Research output: Contribution to journalArticle

Johnson, Kimberly J. ; Williams, Katherine S. ; Ross, Julie A. ; Krailo, Mark D. ; Tomlinson, Gail E. ; Malogolowkin, Marcio ; Feusner, James H. ; Spector, Logan G. / Parental tobacco and alcohol use and risk of hepatoblastoma in offspring : A report from the children's oncology group. In: Cancer Epidemiology Biomarkers and Prevention. 2013 ; Vol. 22, No. 10. pp. 1837-1843.
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title = "Parental tobacco and alcohol use and risk of hepatoblastoma in offspring: A report from the children's oncology group",
abstract = "Background: Hepatoblastoma is a rare pediatric liver tumor that has significantly increased in incidence over the last several decades. The International Agency for Research on Cancer (IARC) recently classified hepatoblastoma as a tobacco-related cancer. Parental alcohol use has shown no association. We examined associations between parental tobacco and alcohol use around the time of pregnancy and hepatoblastoma in a large case-control study. Methods: Maternal interviews were completed for 383 cases diagnosed in the United States during 2000- 2008. Controls (n = 387) were identified through U.S. birth registries and frequency-matched to cases on birth weight, birth year, and region of residence. We used unconditional logistic regression to calculate ORs and 95{\%} confidence intervals (CI) for associations between parental smoking and maternal drinking and offspring hepatoblastoma. Results: We found no association between hepatoblastoma and maternal smoking at any time (OR, 1.0; 95{\%} CI, 0.7-1.4), within the year before pregnancy (OR, 1.1; 95{\%} CI, 0.8-1.6), early in pregnancy (OR, 1.0; 95{\%} CI, 0.7-1.6), or throughout pregnancy (OR, 0.9; 95{\%} CI, 0.5-1.6). We observed marginally positive associations between hepatoblastoma and paternal smoking in the year before pregnancy (OR, 1.4; 95{\%} CI, 1.0-2.0) and during pregnancy (OR, 1.4; 95{\%} CI, 0.9-2.0). Maternal alcohol use was not associated with hepatoblastoma. Conclusion: Our results do not provide evidence for an etiologic relationship between maternal smoking or drinking and hepatoblastoma, and only weak evidence for an association for paternal smoking in the year before pregnancy. Impact: Our study provides limited support for hepatoblastoma as a tobacco-related cancer; however, it remains wise to counsel prospective parents on the merits of smoking cessation.",
author = "Johnson, {Kimberly J.} and Williams, {Katherine S.} and Ross, {Julie A.} and Krailo, {Mark D.} and Tomlinson, {Gail E.} and Marcio Malogolowkin and Feusner, {James H.} and Spector, {Logan G.}",
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T1 - Parental tobacco and alcohol use and risk of hepatoblastoma in offspring

T2 - A report from the children's oncology group

AU - Johnson, Kimberly J.

AU - Williams, Katherine S.

AU - Ross, Julie A.

AU - Krailo, Mark D.

AU - Tomlinson, Gail E.

AU - Malogolowkin, Marcio

AU - Feusner, James H.

AU - Spector, Logan G.

PY - 2013/10/1

Y1 - 2013/10/1

N2 - Background: Hepatoblastoma is a rare pediatric liver tumor that has significantly increased in incidence over the last several decades. The International Agency for Research on Cancer (IARC) recently classified hepatoblastoma as a tobacco-related cancer. Parental alcohol use has shown no association. We examined associations between parental tobacco and alcohol use around the time of pregnancy and hepatoblastoma in a large case-control study. Methods: Maternal interviews were completed for 383 cases diagnosed in the United States during 2000- 2008. Controls (n = 387) were identified through U.S. birth registries and frequency-matched to cases on birth weight, birth year, and region of residence. We used unconditional logistic regression to calculate ORs and 95% confidence intervals (CI) for associations between parental smoking and maternal drinking and offspring hepatoblastoma. Results: We found no association between hepatoblastoma and maternal smoking at any time (OR, 1.0; 95% CI, 0.7-1.4), within the year before pregnancy (OR, 1.1; 95% CI, 0.8-1.6), early in pregnancy (OR, 1.0; 95% CI, 0.7-1.6), or throughout pregnancy (OR, 0.9; 95% CI, 0.5-1.6). We observed marginally positive associations between hepatoblastoma and paternal smoking in the year before pregnancy (OR, 1.4; 95% CI, 1.0-2.0) and during pregnancy (OR, 1.4; 95% CI, 0.9-2.0). Maternal alcohol use was not associated with hepatoblastoma. Conclusion: Our results do not provide evidence for an etiologic relationship between maternal smoking or drinking and hepatoblastoma, and only weak evidence for an association for paternal smoking in the year before pregnancy. Impact: Our study provides limited support for hepatoblastoma as a tobacco-related cancer; however, it remains wise to counsel prospective parents on the merits of smoking cessation.

AB - Background: Hepatoblastoma is a rare pediatric liver tumor that has significantly increased in incidence over the last several decades. The International Agency for Research on Cancer (IARC) recently classified hepatoblastoma as a tobacco-related cancer. Parental alcohol use has shown no association. We examined associations between parental tobacco and alcohol use around the time of pregnancy and hepatoblastoma in a large case-control study. Methods: Maternal interviews were completed for 383 cases diagnosed in the United States during 2000- 2008. Controls (n = 387) were identified through U.S. birth registries and frequency-matched to cases on birth weight, birth year, and region of residence. We used unconditional logistic regression to calculate ORs and 95% confidence intervals (CI) for associations between parental smoking and maternal drinking and offspring hepatoblastoma. Results: We found no association between hepatoblastoma and maternal smoking at any time (OR, 1.0; 95% CI, 0.7-1.4), within the year before pregnancy (OR, 1.1; 95% CI, 0.8-1.6), early in pregnancy (OR, 1.0; 95% CI, 0.7-1.6), or throughout pregnancy (OR, 0.9; 95% CI, 0.5-1.6). We observed marginally positive associations between hepatoblastoma and paternal smoking in the year before pregnancy (OR, 1.4; 95% CI, 1.0-2.0) and during pregnancy (OR, 1.4; 95% CI, 0.9-2.0). Maternal alcohol use was not associated with hepatoblastoma. Conclusion: Our results do not provide evidence for an etiologic relationship between maternal smoking or drinking and hepatoblastoma, and only weak evidence for an association for paternal smoking in the year before pregnancy. Impact: Our study provides limited support for hepatoblastoma as a tobacco-related cancer; however, it remains wise to counsel prospective parents on the merits of smoking cessation.

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