Parental report of the early development of children with regressive autism

The delays-plus-regression phenotype

Sally J Ozonoff, Brenda J. Williams, Rebecca Landa

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

Most children with autism demonstrate developmental abnormalities in their first year, whereas others display regression after mostly normal development. Few studies have examined the early development of the latter group. This study developed a retrospective measure, the Early Development Questionnaire (EDQ), to collect specific, parent-reported information about development in the first 18 months. Based on their EDQ scores, 60 children with autism between the ages of 3 and 9 were divided into three groups: an early onset group (n = 29), a definite regression group (n = 23), and a heterogeneous mixed group (n = 8). Significant differences in early social development were found between the early onset and regression groups. However, over 50 percent of the children who experienced a regression demonstrated some early social deficits during the first year of life, long before regression and the apparent onset of autism. This group, tentatively labeled 'delays-plus-regression', deserves further study.

Original languageEnglish (US)
Pages (from-to)461-486
Number of pages26
JournalAutism
Volume9
Issue number5
DOIs
StatePublished - Dec 2005

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Autistic Disorder
Child Development
Phenotype
Surveys and Questionnaires

Keywords

  • Autism
  • Delays-plus-regression
  • Regressive autism

ASJC Scopus subject areas

  • Psychology(all)
  • Developmental and Educational Psychology

Cite this

Parental report of the early development of children with regressive autism : The delays-plus-regression phenotype. / Ozonoff, Sally J; Williams, Brenda J.; Landa, Rebecca.

In: Autism, Vol. 9, No. 5, 12.2005, p. 461-486.

Research output: Contribution to journalArticle

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