Paraparesis, hypermanganesaemia, and polycythaemia: A novel presentation of cirrhosis

Jr Gospe S.M., R. D. Caruso, M. S. Clegg, Carl L Keen, N. R. Pimstone, Jonathan M Ducore, S. S. Gettner, R. A. Kreutzer

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Progressive myelopathy is a rare complication of chronic hepatic disease which has never been reported in the paediatric age group. We describe the 11 year course of an adolescent male with hepatic myelopathy caused by cryptogenic micronodular cirrhosis. His condition has been associated with persistent polycythaemia and extraordinary increases of whole blood manganese, with magnetic resonance imaging evidence of manganese deposition within the basal ganglia and other regions of the brain. The patient has developed neither liver failure nor parkinsonism. The pathophysiological bases of this multiorgan system disorder are described.

Original languageEnglish (US)
Pages (from-to)439-442
Number of pages4
JournalArchives of Disease in Childhood
Volume83
Issue number5
DOIs
StatePublished - 2000

Keywords

  • Erythropoietin
  • Hepatic myelopathy
  • Manganese
  • Neurotoxicity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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    Gospe S.M., J., Caruso, R. D., Clegg, M. S., Keen, C. L., Pimstone, N. R., Ducore, J. M., Gettner, S. S., & Kreutzer, R. A. (2000). Paraparesis, hypermanganesaemia, and polycythaemia: A novel presentation of cirrhosis. Archives of Disease in Childhood, 83(5), 439-442. https://doi.org/10.1136/adc.83.5.439