Paraneoplastic optic neuropathy and autoantibody production in small-cell carcinoma of the lung

Jennifer E. Luiz, Andrew G. Lee, John L Keltner, Charles E. Thirkill, Eugene C. Lai

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

A 59-year-old woman presented with acute-onset, bilateral, painless loss of vision, dysarthria, and ataxia. Ophthalmoscopy showed bilateral optic disc edema. A magnetic resonance scan of the head was normal. Chest radiography showed mediastinal adenopathy. Mediastinoscopy and biopsy identified small-cell carcinoma of the lung. An autoantibody to optic nerve and retina was demonstrated in the patient's serum. An electroretinogram was normal. The patient was diagnosed with a paraneoplastic optic neuropathy and paraneoplastic cerebellar syndrome. After treatment for her lung cancer, the patient remains stable from a visual and neurologic standpoint.

Original languageEnglish (US)
Pages (from-to)178-181
Number of pages4
JournalJournal of Neuro-Ophthalmology
Volume18
Issue number3
StatePublished - 1998

Keywords

  • Autoantibody
  • Paraneoplastic optic neuropathy
  • Small-cell lung carcinoma

ASJC Scopus subject areas

  • Clinical Neurology
  • Ophthalmology

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