Paraneoplastic limbic encephalitis in a teenage girl with an immature ovarian teratoma

Rebecca Stein-Wexler, Sandra L. Wootton-Gorges, Claudia M. Greco, James A Brunberg

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

Paraneoplastic limbic encephalitis (PLE) is an unusual disorder that is characterized by the association of clinical limbic system abnormalities with neoplasia, usually malignancy. It has rarely been reported in children and then manifests during the teenage years. Diagnosis is often delayed, especially when the tumor has not been recognized. In adults, the diagnosis can be revealed by the presence of antineuronal antibodies. We describe an unusual case of behavioral disturbance leading rapidly to coma in a 14-year-old girl with CSF pleocytosis who was found 10 weeks later to have an immature ovarian teratoma. Although her symptoms eventually improved slightly after tumor excision, she died while in rehabilitation. PLE is an important diagnosis to consider in the teenage girl with symptoms of a progressive limbic disorder and CSF pleocytosis, and whose brain MR imaging demonstrates no abnormality or mild T2-weighted temporal lobe signal abnormality. When this constellation of findings presents in a teenage girl, the possibility of an underlying ovarian teratoma should be considered.

Original languageEnglish (US)
Pages (from-to)694-697
Number of pages4
JournalPediatric Radiology
Volume35
Issue number7
DOIs
StatePublished - Jul 2005

Keywords

  • Ovarian teratoma
  • Paraneoplastic limbic encephalitis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Pediatrics, Perinatology, and Child Health
  • Radiological and Ultrasound Technology

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