Paraneoplastic hypertrophic osteopathy in 30 dogs

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Paraneoplastic hypertrophic osteopathy (pHO) is known to occur in both canine and human cancer patients. While the pathology of pHO is well-described in the dog, very little information exists regarding the true clinical presentation of dogs affected with pHO. The primary objective of this study was to provide a more comprehensive clinical picture of pHO. To this end, we retrospectively identified 30 dogs and recorded data regarding presenting complaints and physical examination (PE) findings on the date of pHO diagnosis. As a secondary objective, any blood test results were also collected from the computerized records. The most common clinical signs included leg swelling, ocular discharge and/or episcleral injection, lameness, and lethargy. The most common haematological and serum biochemical abnormalities included anaemia, neutrophilia and elevated alkaline phosphatase. In addition to presenting a more detailed clinical description of pHO in the dog, these data support the previously described haematological, serum biochemical and PE abnormalities published in individual case reports.

Original languageEnglish (US)
JournalVeterinary and Comparative Oncology
DOIs
StateAccepted/In press - 2013

Fingerprint

Dogs
dogs
Physical Examination
clinical examination
Lethargy
Hematologic Tests
Serum
hematologic tests
Alkaline Phosphatase
Canidae
Anemia
Leg
lameness
anemia
alkaline phosphatase
Pathology
legs
eyes
Injections
case studies

Keywords

  • Comparative oncology
  • Imaging
  • Metastasis
  • Pathology
  • Small animal

ASJC Scopus subject areas

  • veterinary(all)

Cite this

@article{e89d7e3502f541bd821cb94bf25bf23f,
title = "Paraneoplastic hypertrophic osteopathy in 30 dogs",
abstract = "Paraneoplastic hypertrophic osteopathy (pHO) is known to occur in both canine and human cancer patients. While the pathology of pHO is well-described in the dog, very little information exists regarding the true clinical presentation of dogs affected with pHO. The primary objective of this study was to provide a more comprehensive clinical picture of pHO. To this end, we retrospectively identified 30 dogs and recorded data regarding presenting complaints and physical examination (PE) findings on the date of pHO diagnosis. As a secondary objective, any blood test results were also collected from the computerized records. The most common clinical signs included leg swelling, ocular discharge and/or episcleral injection, lameness, and lethargy. The most common haematological and serum biochemical abnormalities included anaemia, neutrophilia and elevated alkaline phosphatase. In addition to presenting a more detailed clinical description of pHO in the dog, these data support the previously described haematological, serum biochemical and PE abnormalities published in individual case reports.",
keywords = "Comparative oncology, Imaging, Metastasis, Pathology, Small animal",
author = "Withers, {S. S.} and Johnson, {Eric G} and Culp, {William T} and Rodriguez, {C. O.} and Skorupski, {Katherine A} and Rebhun, {Robert B}",
year = "2013",
doi = "10.1111/vco.12026",
language = "English (US)",
journal = "Veterinary and Comparative Oncology",
issn = "1476-5829",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Paraneoplastic hypertrophic osteopathy in 30 dogs

AU - Withers, S. S.

AU - Johnson, Eric G

AU - Culp, William T

AU - Rodriguez, C. O.

AU - Skorupski, Katherine A

AU - Rebhun, Robert B

PY - 2013

Y1 - 2013

N2 - Paraneoplastic hypertrophic osteopathy (pHO) is known to occur in both canine and human cancer patients. While the pathology of pHO is well-described in the dog, very little information exists regarding the true clinical presentation of dogs affected with pHO. The primary objective of this study was to provide a more comprehensive clinical picture of pHO. To this end, we retrospectively identified 30 dogs and recorded data regarding presenting complaints and physical examination (PE) findings on the date of pHO diagnosis. As a secondary objective, any blood test results were also collected from the computerized records. The most common clinical signs included leg swelling, ocular discharge and/or episcleral injection, lameness, and lethargy. The most common haematological and serum biochemical abnormalities included anaemia, neutrophilia and elevated alkaline phosphatase. In addition to presenting a more detailed clinical description of pHO in the dog, these data support the previously described haematological, serum biochemical and PE abnormalities published in individual case reports.

AB - Paraneoplastic hypertrophic osteopathy (pHO) is known to occur in both canine and human cancer patients. While the pathology of pHO is well-described in the dog, very little information exists regarding the true clinical presentation of dogs affected with pHO. The primary objective of this study was to provide a more comprehensive clinical picture of pHO. To this end, we retrospectively identified 30 dogs and recorded data regarding presenting complaints and physical examination (PE) findings on the date of pHO diagnosis. As a secondary objective, any blood test results were also collected from the computerized records. The most common clinical signs included leg swelling, ocular discharge and/or episcleral injection, lameness, and lethargy. The most common haematological and serum biochemical abnormalities included anaemia, neutrophilia and elevated alkaline phosphatase. In addition to presenting a more detailed clinical description of pHO in the dog, these data support the previously described haematological, serum biochemical and PE abnormalities published in individual case reports.

KW - Comparative oncology

KW - Imaging

KW - Metastasis

KW - Pathology

KW - Small animal

UR - http://www.scopus.com/inward/record.url?scp=84874934340&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84874934340&partnerID=8YFLogxK

U2 - 10.1111/vco.12026

DO - 10.1111/vco.12026

M3 - Article

C2 - 23489591

AN - SCOPUS:84939651486

JO - Veterinary and Comparative Oncology

JF - Veterinary and Comparative Oncology

SN - 1476-5829

ER -