Parallels between the Antiviral State and the Irradiated State

Heather M. McGee, Ariel E. Marciscano, Allison M. Campbell, Arta M. Monjazeb, Susan M. Kaech, John R. Teijaro

Research output: Contribution to journalReview articlepeer-review

Abstract

Improved understanding of host antiviral defense and antitumor immunity have elucidated molecular pathways important to both processes. During viral infection, RNA or DNA in the host cell serves as a danger signal that initiates the antiviral response. Recent studies have elucidated similarities in the signaling pathways activated by viruses and the signaling pathways induced by tumor DNA that is released into the cytoplasm of irradiated tumor cells. Both the host defense to viral infection and the sterile inflammation provoked by radiotherapy induce a type I interferon response that is necessary for pathogen control and immune-mediated tumor control, respectively. These findings have led to the hypothesis that radiotherapy employs a form of viral mimicry.

Original languageEnglish (US)
Pages (from-to)969-979
Number of pages11
JournalJournal of the National Cancer Institute
Volume113
Issue number8
DOIs
StatePublished - Aug 1 2021

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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