Parallel chemoenzymatic synthesis of sialosides containing a C5-diversified sialic acid

Hongzhi Cao, Saddam Muthana, Yanhong Li, Jiansong Cheng, Xi Chen

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

A convenient chemoenzymatic strategy for synthesizing sialosides containing a C5-diversified sialic acid was developed. The α2,3- and α2,6-linked sialosides containing a 5-azido neuraminic acid synthesized by a highly efficient one-pot three-enzyme approach were converted to C5″-amino sialosides, which were used as common intermediates for chemical parallel synthesis to quickly generate a series of sialosides containing various sialic acid forms.

Original languageEnglish (US)
Pages (from-to)5869-5871
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume19
Issue number20
DOIs
StatePublished - Oct 15 2009

Keywords

  • Carbohydrates
  • Chemoenzymatic synthesis
  • Enzymes
  • Parallel synthesis
  • Sialic acid
  • Sialosides

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

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