Paradoxical imaging findings in cerebral gliomas

Marie Atkinson, Csaba Juhász, Jagdish Shah, Xi Guo, William Kupsky, Darren Fuerst, Robert Johnson, Craig Watson

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Gliomas represent approximately one-third of all intracranial tumors in adults and commonly present clinically with seizures. We report two seizure patients with paradoxical imaging findings on preoperative grading of their cerebral gliomas. A 53-year-old man with a history of temporal lobe epilepsy originating from a mass in the right medial temporal region (patient 1) and a 44-year-old man with a history of predominantly left sided sensory seizures with a mass in the right posterior parietal region (patient 2) underwent presurgical evaluation including MRI and glucose PET, followed by surgery to remove cerebral tumors associated with seizure onset. Preoperatively, patient 1 had a homogenous non-enhancing lesion on MRI and hypometabolism on PET imaging, suggesting a low-grade tumor. Postoperative histopathology was consistent with a glioblastoma multiforme (grade IV). Patient 2 had a heterogeneous lesion with cyst formation, edema, and contrast enhancement on preoperative MRI imaging, and interictal hypermetabolism on PET scan, thus suggesting a high-grade tumor. Postoperative histopathology was consistent with an oligodendroglioma (grade II) without anaplastic features. We conclude preoperative grading of cerebral gliomas may be inaccurate occasionally even in cases with concordant structural and functional imaging findings. This should be considered when counseling patients.

Original languageEnglish (US)
Pages (from-to)180-183
Number of pages4
JournalJournal of the Neurological Sciences
Volume269
Issue number1-2
DOIs
StatePublished - Jun 15 2008
Externally publishedYes

Fingerprint

Glioma
Seizures
Neoplasms
Oligodendroglioma
Parietal Lobe
Temporal Lobe Epilepsy
Temporal Lobe
Glioblastoma
Positron-Emission Tomography
Cysts
Counseling
Edema
Glucose

Keywords

  • Epilepsy surgery
  • MRI, PET
  • Primary brain tumors
  • Surgical therapy-tumor

ASJC Scopus subject areas

  • Aging
  • Clinical Neurology
  • Surgery
  • Developmental Neuroscience
  • Neurology
  • Neuroscience(all)

Cite this

Atkinson, M., Juhász, C., Shah, J., Guo, X., Kupsky, W., Fuerst, D., ... Watson, C. (2008). Paradoxical imaging findings in cerebral gliomas. Journal of the Neurological Sciences, 269(1-2), 180-183. https://doi.org/10.1016/j.jns.2007.12.029

Paradoxical imaging findings in cerebral gliomas. / Atkinson, Marie; Juhász, Csaba; Shah, Jagdish; Guo, Xi; Kupsky, William; Fuerst, Darren; Johnson, Robert; Watson, Craig.

In: Journal of the Neurological Sciences, Vol. 269, No. 1-2, 15.06.2008, p. 180-183.

Research output: Contribution to journalArticle

Atkinson, M, Juhász, C, Shah, J, Guo, X, Kupsky, W, Fuerst, D, Johnson, R & Watson, C 2008, 'Paradoxical imaging findings in cerebral gliomas', Journal of the Neurological Sciences, vol. 269, no. 1-2, pp. 180-183. https://doi.org/10.1016/j.jns.2007.12.029
Atkinson M, Juhász C, Shah J, Guo X, Kupsky W, Fuerst D et al. Paradoxical imaging findings in cerebral gliomas. Journal of the Neurological Sciences. 2008 Jun 15;269(1-2):180-183. https://doi.org/10.1016/j.jns.2007.12.029
Atkinson, Marie ; Juhász, Csaba ; Shah, Jagdish ; Guo, Xi ; Kupsky, William ; Fuerst, Darren ; Johnson, Robert ; Watson, Craig. / Paradoxical imaging findings in cerebral gliomas. In: Journal of the Neurological Sciences. 2008 ; Vol. 269, No. 1-2. pp. 180-183.
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