Paper: Use of a gonadotrophin-releasing hormone vaccine in headshaking horses

K. J. Pickles; J. Berger; R. Davies; J. Roser; John E Madigan

doi:10.1136/vr.c5992

Paper: Use of a gonadotrophin-releasing hormone vaccine in headshaking horses

K. J. Pickles, J. Berger, R. Davies, J. Roser, John E Madigan

Medicine and Epidemiology

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

The aim of this study was to investigate the use of a gonadotrophin- releasing hormone (GnRH) vaccine in the treatment of headshaking in horses. Fifteen geldings received two doses of the GnRH vaccine four weeks apart. Serum was collected before and after vaccination to measure concentrations of luteinising hormone (LH) (10 horses) and follicle-stimulating hormone (FSH) (six horses). Owners recorded the frequency of seven common headshaking behaviours using a visual analogue scale (VAS) before vaccination and at two, four, eight, 12, 16 and 20 weeks after vaccination. Serum LH (P=0.008) and FSH (P=0.03) concentrations decreased significantly following vaccination. Although approximately one-third of the owners reported a subjective improvement in headshaking, serial scoring did not indicate a reduction in headshaking behaviours following vaccination with a commercial GnRH vaccine. Vaccination reactions were observed in four of 15 horses (27 per cent), including one case of severe, presumed immune-mediated, myositis.

Original language	English (US)
Pages (from-to)	19
Number of pages	1
Journal	Veterinary Record
Volume	168
Issue number	1
DOIs	https://doi.org/10.1136/vr.c5992
State	Published - Jan 1 2011

ASJC Scopus subject areas

veterinary(all)

Access to Document

10.1136/vr.c5992

Cite this

@article{4a8ec35c004d411ea854404f2aee2382,

title = "Paper: Use of a gonadotrophin-releasing hormone vaccine in headshaking horses",

abstract = "The aim of this study was to investigate the use of a gonadotrophin- releasing hormone (GnRH) vaccine in the treatment of headshaking in horses. Fifteen geldings received two doses of the GnRH vaccine four weeks apart. Serum was collected before and after vaccination to measure concentrations of luteinising hormone (LH) (10 horses) and follicle-stimulating hormone (FSH) (six horses). Owners recorded the frequency of seven common headshaking behaviours using a visual analogue scale (VAS) before vaccination and at two, four, eight, 12, 16 and 20 weeks after vaccination. Serum LH (P=0.008) and FSH (P=0.03) concentrations decreased significantly following vaccination. Although approximately one-third of the owners reported a subjective improvement in headshaking, serial scoring did not indicate a reduction in headshaking behaviours following vaccination with a commercial GnRH vaccine. Vaccination reactions were observed in four of 15 horses (27 per cent), including one case of severe, presumed immune-mediated, myositis.",

author = "Pickles, {K. J.} and J. Berger and R. Davies and J. Roser and Madigan, {John E}",

year = "2011",

month = jan,

day = "1",

doi = "10.1136/vr.c5992",

language = "English (US)",

volume = "168",

pages = "19",

journal = "Veterinary Record",

issn = "0042-4900",

publisher = "British Veterinary Association",

number = "1",

}

TY - JOUR

T1 - Paper

T2 - Use of a gonadotrophin-releasing hormone vaccine in headshaking horses

AU - Pickles, K. J.

AU - Berger, J.

AU - Davies, R.

AU - Roser, J.

AU - Madigan, John E

PY - 2011/1/1

Y1 - 2011/1/1

N2 - The aim of this study was to investigate the use of a gonadotrophin- releasing hormone (GnRH) vaccine in the treatment of headshaking in horses. Fifteen geldings received two doses of the GnRH vaccine four weeks apart. Serum was collected before and after vaccination to measure concentrations of luteinising hormone (LH) (10 horses) and follicle-stimulating hormone (FSH) (six horses). Owners recorded the frequency of seven common headshaking behaviours using a visual analogue scale (VAS) before vaccination and at two, four, eight, 12, 16 and 20 weeks after vaccination. Serum LH (P=0.008) and FSH (P=0.03) concentrations decreased significantly following vaccination. Although approximately one-third of the owners reported a subjective improvement in headshaking, serial scoring did not indicate a reduction in headshaking behaviours following vaccination with a commercial GnRH vaccine. Vaccination reactions were observed in four of 15 horses (27 per cent), including one case of severe, presumed immune-mediated, myositis.

AB - The aim of this study was to investigate the use of a gonadotrophin- releasing hormone (GnRH) vaccine in the treatment of headshaking in horses. Fifteen geldings received two doses of the GnRH vaccine four weeks apart. Serum was collected before and after vaccination to measure concentrations of luteinising hormone (LH) (10 horses) and follicle-stimulating hormone (FSH) (six horses). Owners recorded the frequency of seven common headshaking behaviours using a visual analogue scale (VAS) before vaccination and at two, four, eight, 12, 16 and 20 weeks after vaccination. Serum LH (P=0.008) and FSH (P=0.03) concentrations decreased significantly following vaccination. Although approximately one-third of the owners reported a subjective improvement in headshaking, serial scoring did not indicate a reduction in headshaking behaviours following vaccination with a commercial GnRH vaccine. Vaccination reactions were observed in four of 15 horses (27 per cent), including one case of severe, presumed immune-mediated, myositis.

UR - http://www.scopus.com/inward/record.url?scp=79952270729&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79952270729&partnerID=8YFLogxK

U2 - 10.1136/vr.c5992

DO - 10.1136/vr.c5992

M3 - Article

C2 - 21257532

AN - SCOPUS:79952270729

VL - 168

SP - 19

JO - Veterinary Record

JF - Veterinary Record

SN - 0042-4900

IS - 1

ER -

Paper: Use of a gonadotrophin-releasing hormone vaccine in headshaking horses

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this