Paper: Use of a gonadotrophin-releasing hormone vaccine in headshaking horses

K. J. Pickles, J. Berger, R. Davies, J. Roser, John E Madigan

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The aim of this study was to investigate the use of a gonadotrophin- releasing hormone (GnRH) vaccine in the treatment of headshaking in horses. Fifteen geldings received two doses of the GnRH vaccine four weeks apart. Serum was collected before and after vaccination to measure concentrations of luteinising hormone (LH) (10 horses) and follicle-stimulating hormone (FSH) (six horses). Owners recorded the frequency of seven common headshaking behaviours using a visual analogue scale (VAS) before vaccination and at two, four, eight, 12, 16 and 20 weeks after vaccination. Serum LH (P=0.008) and FSH (P=0.03) concentrations decreased significantly following vaccination. Although approximately one-third of the owners reported a subjective improvement in headshaking, serial scoring did not indicate a reduction in headshaking behaviours following vaccination with a commercial GnRH vaccine. Vaccination reactions were observed in four of 15 horses (27 per cent), including one case of severe, presumed immune-mediated, myositis.

Original languageEnglish (US)
Pages (from-to)19
Number of pages1
JournalVeterinary Record
Volume168
Issue number1
DOIs
StatePublished - Jan 1 2011

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gonadotropin-releasing hormone
Gonadotropin-Releasing Hormone
Horses
Vaccination
Vaccines
vaccination
vaccines
horses
follicle-stimulating hormone
Follicle Stimulating Hormone
luteinizing hormone
Luteinizing Hormone
myositis
Myositis
geldings
Serum
Visual Analog Scale
dosage

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Paper : Use of a gonadotrophin-releasing hormone vaccine in headshaking horses. / Pickles, K. J.; Berger, J.; Davies, R.; Roser, J.; Madigan, John E.

In: Veterinary Record, Vol. 168, No. 1, 01.01.2011, p. 19.

Research output: Contribution to journalArticle

Pickles, K. J. ; Berger, J. ; Davies, R. ; Roser, J. ; Madigan, John E. / Paper : Use of a gonadotrophin-releasing hormone vaccine in headshaking horses. In: Veterinary Record. 2011 ; Vol. 168, No. 1. pp. 19.
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