Abstract
The aim of this study was to investigate the use of a gonadotrophin- releasing hormone (GnRH) vaccine in the treatment of headshaking in horses. Fifteen geldings received two doses of the GnRH vaccine four weeks apart. Serum was collected before and after vaccination to measure concentrations of luteinising hormone (LH) (10 horses) and follicle-stimulating hormone (FSH) (six horses). Owners recorded the frequency of seven common headshaking behaviours using a visual analogue scale (VAS) before vaccination and at two, four, eight, 12, 16 and 20 weeks after vaccination. Serum LH (P=0.008) and FSH (P=0.03) concentrations decreased significantly following vaccination. Although approximately one-third of the owners reported a subjective improvement in headshaking, serial scoring did not indicate a reduction in headshaking behaviours following vaccination with a commercial GnRH vaccine. Vaccination reactions were observed in four of 15 horses (27 per cent), including one case of severe, presumed immune-mediated, myositis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 19 |
| Number of pages | 1 |
| Journal | Veterinary Record |
| Volume | 168 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2011 |
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ASJC Scopus subject areas
- veterinary(all)
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Paper : Use of a gonadotrophin-releasing hormone vaccine in headshaking horses. / Pickles, K. J.; Berger, J.; Davies, R.; Roser, J.; Madigan, John E.
In: Veterinary Record, Vol. 168, No. 1, 01.01.2011, p. 19.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Paper
T2 - Use of a gonadotrophin-releasing hormone vaccine in headshaking horses
AU - Pickles, K. J.
AU - Berger, J.
AU - Davies, R.
AU - Roser, J.
AU - Madigan, John E
PY - 2011/1/1
Y1 - 2011/1/1
N2 - The aim of this study was to investigate the use of a gonadotrophin- releasing hormone (GnRH) vaccine in the treatment of headshaking in horses. Fifteen geldings received two doses of the GnRH vaccine four weeks apart. Serum was collected before and after vaccination to measure concentrations of luteinising hormone (LH) (10 horses) and follicle-stimulating hormone (FSH) (six horses). Owners recorded the frequency of seven common headshaking behaviours using a visual analogue scale (VAS) before vaccination and at two, four, eight, 12, 16 and 20 weeks after vaccination. Serum LH (P=0.008) and FSH (P=0.03) concentrations decreased significantly following vaccination. Although approximately one-third of the owners reported a subjective improvement in headshaking, serial scoring did not indicate a reduction in headshaking behaviours following vaccination with a commercial GnRH vaccine. Vaccination reactions were observed in four of 15 horses (27 per cent), including one case of severe, presumed immune-mediated, myositis.
AB - The aim of this study was to investigate the use of a gonadotrophin- releasing hormone (GnRH) vaccine in the treatment of headshaking in horses. Fifteen geldings received two doses of the GnRH vaccine four weeks apart. Serum was collected before and after vaccination to measure concentrations of luteinising hormone (LH) (10 horses) and follicle-stimulating hormone (FSH) (six horses). Owners recorded the frequency of seven common headshaking behaviours using a visual analogue scale (VAS) before vaccination and at two, four, eight, 12, 16 and 20 weeks after vaccination. Serum LH (P=0.008) and FSH (P=0.03) concentrations decreased significantly following vaccination. Although approximately one-third of the owners reported a subjective improvement in headshaking, serial scoring did not indicate a reduction in headshaking behaviours following vaccination with a commercial GnRH vaccine. Vaccination reactions were observed in four of 15 horses (27 per cent), including one case of severe, presumed immune-mediated, myositis.
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UR - http://www.scopus.com/inward/citedby.url?scp=79952270729&partnerID=8YFLogxK
U2 - 10.1136/vr.c5992
DO - 10.1136/vr.c5992
M3 - Article
C2 - 21257532
AN - SCOPUS:79952270729
VL - 168
SP - 19
JO - Veterinary Record
JF - Veterinary Record
SN - 0042-4900
IS - 1
ER -