Paper: Use of a gonadotrophin-releasing hormone vaccine in headshaking horses

K. J. Pickles; J. Berger; R. Davies; J. Roser; John E Madigan

doi:10.1136/vr.c5992

Paper: Use of a gonadotrophin-releasing hormone vaccine in headshaking horses

K. J. Pickles, J. Berger, R. Davies, J. Roser, John E Madigan

Medicine and Epidemiology

Research output: Contribution to journal › Article › peer-review

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Abstract

The aim of this study was to investigate the use of a gonadotrophin- releasing hormone (GnRH) vaccine in the treatment of headshaking in horses. Fifteen geldings received two doses of the GnRH vaccine four weeks apart. Serum was collected before and after vaccination to measure concentrations of luteinising hormone (LH) (10 horses) and follicle-stimulating hormone (FSH) (six horses). Owners recorded the frequency of seven common headshaking behaviours using a visual analogue scale (VAS) before vaccination and at two, four, eight, 12, 16 and 20 weeks after vaccination. Serum LH (P=0.008) and FSH (P=0.03) concentrations decreased significantly following vaccination. Although approximately one-third of the owners reported a subjective improvement in headshaking, serial scoring did not indicate a reduction in headshaking behaviours following vaccination with a commercial GnRH vaccine. Vaccination reactions were observed in four of 15 horses (27 per cent), including one case of severe, presumed immune-mediated, myositis.

Original language	English (US)
Pages (from-to)	19
Number of pages	1
Journal	Veterinary Record
Volume	168
Issue number	1
DOIs	https://doi.org/10.1136/vr.c5992
State	Published - Jan 1 2011

ASJC Scopus subject areas

veterinary(all)

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10.1136/vr.c5992

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abstract = "The aim of this study was to investigate the use of a gonadotrophin- releasing hormone (GnRH) vaccine in the treatment of headshaking in horses. Fifteen geldings received two doses of the GnRH vaccine four weeks apart. Serum was collected before and after vaccination to measure concentrations of luteinising hormone (LH) (10 horses) and follicle-stimulating hormone (FSH) (six horses). Owners recorded the frequency of seven common headshaking behaviours using a visual analogue scale (VAS) before vaccination and at two, four, eight, 12, 16 and 20 weeks after vaccination. Serum LH (P=0.008) and FSH (P=0.03) concentrations decreased significantly following vaccination. Although approximately one-third of the owners reported a subjective improvement in headshaking, serial scoring did not indicate a reduction in headshaking behaviours following vaccination with a commercial GnRH vaccine. Vaccination reactions were observed in four of 15 horses (27 per cent), including one case of severe, presumed immune-mediated, myositis.",

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Paper: Use of a gonadotrophin-releasing hormone vaccine in headshaking horses

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