Abstract
Building and maintaining a homeostatic relationship between a host and its colonizing microbiota entails ongoing complex interactions between the host and the microorganisms. The mucosal immune system, including epithelial cells, plays an essential part in negotiating this equilibrium. Paneth cells (specialized cells in the epithelium of the small intestine) are an important source of antimicrobial peptides in the intestine. These cells have become the focus of investigations that explore the mechanisms of hostĝ€" microorganism homeostasis in the small intestine and its collapse in the processes of infection and chronic inflammation. In this Review, we provide an overview of the intestinal microbiota and describe the cell biology of Paneth cells, emphasizing the composition of their secretions and the roles of these cells in intestinal host defence and homeostasis. We also highlight the implications of Paneth cell dysfunction in susceptibility to chronic inflammatory bowel disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 356-368 |
| Number of pages | 13 |
| Journal | Nature Reviews Microbiology |
| Volume | 9 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 2011 |
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ASJC Scopus subject areas
- Immunology and Microbiology(all)
Cite this
Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis. / Bevins, Charles L; Salzman, Nita H.
In: Nature Reviews Microbiology, Vol. 9, No. 5, 05.2011, p. 356-368.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis
AU - Bevins, Charles L
AU - Salzman, Nita H.
PY - 2011/5
Y1 - 2011/5
N2 - Building and maintaining a homeostatic relationship between a host and its colonizing microbiota entails ongoing complex interactions between the host and the microorganisms. The mucosal immune system, including epithelial cells, plays an essential part in negotiating this equilibrium. Paneth cells (specialized cells in the epithelium of the small intestine) are an important source of antimicrobial peptides in the intestine. These cells have become the focus of investigations that explore the mechanisms of hostĝ€" microorganism homeostasis in the small intestine and its collapse in the processes of infection and chronic inflammation. In this Review, we provide an overview of the intestinal microbiota and describe the cell biology of Paneth cells, emphasizing the composition of their secretions and the roles of these cells in intestinal host defence and homeostasis. We also highlight the implications of Paneth cell dysfunction in susceptibility to chronic inflammatory bowel disease.
AB - Building and maintaining a homeostatic relationship between a host and its colonizing microbiota entails ongoing complex interactions between the host and the microorganisms. The mucosal immune system, including epithelial cells, plays an essential part in negotiating this equilibrium. Paneth cells (specialized cells in the epithelium of the small intestine) are an important source of antimicrobial peptides in the intestine. These cells have become the focus of investigations that explore the mechanisms of hostĝ€" microorganism homeostasis in the small intestine and its collapse in the processes of infection and chronic inflammation. In this Review, we provide an overview of the intestinal microbiota and describe the cell biology of Paneth cells, emphasizing the composition of their secretions and the roles of these cells in intestinal host defence and homeostasis. We also highlight the implications of Paneth cell dysfunction in susceptibility to chronic inflammatory bowel disease.
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UR - http://www.scopus.com/inward/citedby.url?scp=79954915318&partnerID=8YFLogxK
U2 - 10.1038/nrmicro2546
DO - 10.1038/nrmicro2546
M3 - Article
C2 - 21423246
AN - SCOPUS:79954915318
VL - 9
SP - 356
EP - 368
JO - Nature Reviews Microbiology
JF - Nature Reviews Microbiology
SN - 1740-1526
IS - 5
ER -