Paneth cells and antibacterial host defense in neonatal small intestine

Michael P. Sherman, Stephen H. Bennett, Freda F Y Hwang, Jan Sherman, Charles L Bevins

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Paneth cells are specialized epithelia in the small bowel that secrete antimicrobial proteins. Paneth cells are vital to the innate immunity of the small bowel in adult mammals, but their role during neonatal infection of the small bowel is not well established. Dithizone selectively damages Paneth cells, and when dithizone-treated newborn rats are infected enterally with Escherichia coli, the numbers of E. coli cells in their jejunal and ileal lavage fluid are significantly increased compared to controls. The data support that Paneth cells are necessary for neonatal antibacterial defense.

Original languageEnglish (US)
Pages (from-to)6143-6146
Number of pages4
JournalInfection and Immunity
Volume73
Issue number9
DOIs
StatePublished - Sep 2005

Fingerprint

Paneth Cells
Small Intestine
Dithizone
Escherichia coli
Therapeutic Irrigation
Innate Immunity
Mammals
Epithelium
Infection
Proteins

ASJC Scopus subject areas

  • Immunology

Cite this

Paneth cells and antibacterial host defense in neonatal small intestine. / Sherman, Michael P.; Bennett, Stephen H.; Hwang, Freda F Y; Sherman, Jan; Bevins, Charles L.

In: Infection and Immunity, Vol. 73, No. 9, 09.2005, p. 6143-6146.

Research output: Contribution to journalArticle

Sherman, Michael P. ; Bennett, Stephen H. ; Hwang, Freda F Y ; Sherman, Jan ; Bevins, Charles L. / Paneth cells and antibacterial host defense in neonatal small intestine. In: Infection and Immunity. 2005 ; Vol. 73, No. 9. pp. 6143-6146.
@article{a78b107b93394970bf15758825e188b2,
title = "Paneth cells and antibacterial host defense in neonatal small intestine",
abstract = "Paneth cells are specialized epithelia in the small bowel that secrete antimicrobial proteins. Paneth cells are vital to the innate immunity of the small bowel in adult mammals, but their role during neonatal infection of the small bowel is not well established. Dithizone selectively damages Paneth cells, and when dithizone-treated newborn rats are infected enterally with Escherichia coli, the numbers of E. coli cells in their jejunal and ileal lavage fluid are significantly increased compared to controls. The data support that Paneth cells are necessary for neonatal antibacterial defense.",
author = "Sherman, {Michael P.} and Bennett, {Stephen H.} and Hwang, {Freda F Y} and Jan Sherman and Bevins, {Charles L}",
year = "2005",
month = "9",
doi = "10.1128/IAI.73.9.6143-6146.2005",
language = "English (US)",
volume = "73",
pages = "6143--6146",
journal = "Infection and Immunity",
issn = "0019-9567",
publisher = "American Society for Microbiology",
number = "9",

}

TY - JOUR

T1 - Paneth cells and antibacterial host defense in neonatal small intestine

AU - Sherman, Michael P.

AU - Bennett, Stephen H.

AU - Hwang, Freda F Y

AU - Sherman, Jan

AU - Bevins, Charles L

PY - 2005/9

Y1 - 2005/9

N2 - Paneth cells are specialized epithelia in the small bowel that secrete antimicrobial proteins. Paneth cells are vital to the innate immunity of the small bowel in adult mammals, but their role during neonatal infection of the small bowel is not well established. Dithizone selectively damages Paneth cells, and when dithizone-treated newborn rats are infected enterally with Escherichia coli, the numbers of E. coli cells in their jejunal and ileal lavage fluid are significantly increased compared to controls. The data support that Paneth cells are necessary for neonatal antibacterial defense.

AB - Paneth cells are specialized epithelia in the small bowel that secrete antimicrobial proteins. Paneth cells are vital to the innate immunity of the small bowel in adult mammals, but their role during neonatal infection of the small bowel is not well established. Dithizone selectively damages Paneth cells, and when dithizone-treated newborn rats are infected enterally with Escherichia coli, the numbers of E. coli cells in their jejunal and ileal lavage fluid are significantly increased compared to controls. The data support that Paneth cells are necessary for neonatal antibacterial defense.

UR - http://www.scopus.com/inward/record.url?scp=23944464510&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=23944464510&partnerID=8YFLogxK

U2 - 10.1128/IAI.73.9.6143-6146.2005

DO - 10.1128/IAI.73.9.6143-6146.2005

M3 - Article

C2 - 16113336

AN - SCOPUS:23944464510

VL - 73

SP - 6143

EP - 6146

JO - Infection and Immunity

JF - Infection and Immunity

SN - 0019-9567

IS - 9

ER -