Pancreatic hypersensitivity to glucose by young obese Zucker rats ( fa fa)

Amy Kuffert; Judith S. Stern; Donald L. Curry

doi:10.1016/0026-0495(88)90152-7

Pancreatic hypersensitivity to glucose by young obese Zucker rats ( fa fa)

Amy Kuffert, Judith S. Stern, Donald L. Curry

Endocrinology, Diabetes, and Metabolism

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Insulin secretory response to glucose was investigated in 5- to 6-week-old male Zucker obese ( fa fa) and lean ( Fa Fa) rats using a pancreatic perfusion procedure. Blood glucose response to fasting was studied in lean and obese animals over 24 hours. Plasma glucose was slightly elevated in pentobarbital-anesthetized obese rats. However, plasma insulin was 4.6 times greater than that of leans. A hypoglycemic glucose stimulus (75 mg/dL) caused pancreata from obese animals to release 6 times more insulin than lean animals. Stimuli of 125 mg/dL (normoglycemic) and 600 mg/dL (hyperglycemic) caused hypersecretion of 8 and 5 times, respectively. Hyersecretion was not accounted for solely by the twofold increase in pancreatic insulin content. Obese animals has steeper decreases in plasma glucose than lean controls during seven to 13 hours of fasting. Hypersecretion by pancreata from young obese rats to physiological levels of glucose may result in hyperphagia in order to maintain normoglycemia.

Original language	English (US)
Pages (from-to)	952-957
Number of pages	6
Journal	Metabolism
Volume	37
Issue number	10
DOIs	https://doi.org/10.1016/0026-0495(88)90152-7
State	Published - 1988

ASJC Scopus subject areas

Endocrinology
Endocrinology, Diabetes and Metabolism

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title = "Pancreatic hypersensitivity to glucose by young obese Zucker rats ( fa fa)",

abstract = "Insulin secretory response to glucose was investigated in 5- to 6-week-old male Zucker obese ( fa fa) and lean ( Fa Fa) rats using a pancreatic perfusion procedure. Blood glucose response to fasting was studied in lean and obese animals over 24 hours. Plasma glucose was slightly elevated in pentobarbital-anesthetized obese rats. However, plasma insulin was 4.6 times greater than that of leans. A hypoglycemic glucose stimulus (75 mg/dL) caused pancreata from obese animals to release 6 times more insulin than lean animals. Stimuli of 125 mg/dL (normoglycemic) and 600 mg/dL (hyperglycemic) caused hypersecretion of 8 and 5 times, respectively. Hyersecretion was not accounted for solely by the twofold increase in pancreatic insulin content. Obese animals has steeper decreases in plasma glucose than lean controls during seven to 13 hours of fasting. Hypersecretion by pancreata from young obese rats to physiological levels of glucose may result in hyperphagia in order to maintain normoglycemia.",

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AU - Stern, Judith S.

AU - Curry, Donald L.

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