Pancreas graft loss caused by intra-abdominal infection

A risk factor for a subsequent pancreas retransplantation

Enrico Benedetti, Christoph Troppmann, Angelika C. Gruessner, David E R Sutherland, David L. Dunn, Rainer W G Gruessner

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Objective: To investigate whether previous pancreas graft loss caused by intra-abdominal infection is a risk factor for a subsequent pancreas retransplantation. Design: Retrospective case-series analysis. Setting: Large university hospital. Patients: Of 97 pancreatic retransplantations (July 1, 1985 to June 30, 1994), 13 (13%) were performed after previous pancreas grafts had been lost because of intraabdominal infection. Main Outcome Measures: Cause of retransplant graft loss; patient survival. Results: Of 13 cases of pancreatic retransplantations performed after previous grafts had been lost because of intraabdominal infection, 12 (92%) were again complicated by intra-abdominal infection. Of these 12 retransplantation infections, 10 were caused by the same microbial species that had caused failure of the previous graft 1 to 5 years earlier (8 required graft pancreatectomy [mortality rate, 25%], and 2 were successfully treated) and 2 were caused by different microbial species (both required graft pancreatectomy [mortality rate, 0%]). In 1 of the 13 retransplantations, prophylactic antimicrobial treatment was directed at the microbial species that had caused failure of the previous graft; no recurrent intraabdominal infection developed. Conclusions: Intra-abdominal infection after a previous pancreas transplantation is a risk factor for recurrence of infection by the same microbial species after a subsequent retransplantation. For the selected patients who are considered for retransplantation in spite of their previous graft loss caused by intra-abdominal infection, periretransplantation antimicrobial prophylaxis should include a prolonged course of an agent directed against the previously identified microbial species.

Original languageEnglish (US)
Pages (from-to)1054-1060
Number of pages7
JournalArchives of Surgery
Volume131
Issue number10
StatePublished - Oct 1996
Externally publishedYes

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Intraabdominal Infections
Pancreas
Transplants
Pancreatectomy
Pancreas Transplantation
Mortality
Infection
Outcome Assessment (Health Care)
Recurrence

ASJC Scopus subject areas

  • Surgery

Cite this

Benedetti, E., Troppmann, C., Gruessner, A. C., Sutherland, D. E. R., Dunn, D. L., & Gruessner, R. W. G. (1996). Pancreas graft loss caused by intra-abdominal infection: A risk factor for a subsequent pancreas retransplantation. Archives of Surgery, 131(10), 1054-1060.

Pancreas graft loss caused by intra-abdominal infection : A risk factor for a subsequent pancreas retransplantation. / Benedetti, Enrico; Troppmann, Christoph; Gruessner, Angelika C.; Sutherland, David E R; Dunn, David L.; Gruessner, Rainer W G.

In: Archives of Surgery, Vol. 131, No. 10, 10.1996, p. 1054-1060.

Research output: Contribution to journalArticle

Benedetti, E, Troppmann, C, Gruessner, AC, Sutherland, DER, Dunn, DL & Gruessner, RWG 1996, 'Pancreas graft loss caused by intra-abdominal infection: A risk factor for a subsequent pancreas retransplantation', Archives of Surgery, vol. 131, no. 10, pp. 1054-1060.
Benedetti E, Troppmann C, Gruessner AC, Sutherland DER, Dunn DL, Gruessner RWG. Pancreas graft loss caused by intra-abdominal infection: A risk factor for a subsequent pancreas retransplantation. Archives of Surgery. 1996 Oct;131(10):1054-1060.
Benedetti, Enrico ; Troppmann, Christoph ; Gruessner, Angelika C. ; Sutherland, David E R ; Dunn, David L. ; Gruessner, Rainer W G. / Pancreas graft loss caused by intra-abdominal infection : A risk factor for a subsequent pancreas retransplantation. In: Archives of Surgery. 1996 ; Vol. 131, No. 10. pp. 1054-1060.
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