Abstract
Dialytic ultrafiltration with haemofilter was performed in 16 patients with malignant ascites refractory to treatment with sodium restriction, diuretic and systemic chemotherapy. A continuous flow of ascitic fluid at a rate of 300–400 ml/min through a haemofilter was maintained by a blood pump. The protein‐rich ascitic fluid was re‐infused into the peritoneal cavity with sodium and water removed. An average of 5.2 1 of filtrate was removed over a mean interval of 3.5 h. Bleomycin (60 mg) was administered intraperitoneally following the procedure. Complete response was observed in six patients (37.25%) and partial response occurred in four (25%). The remaining patients showed no response. Complications of the dialytic ultrafiltration procedure and toxicity of intraperitoneal administration of bleomycin were minimal. The technique of dialytic ultrafiltration is simple, safe and cost‐effective and could be used as an adjuvant therapy for intraperitoneal chemotherapy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 467-472 |
| Number of pages | 6 |
| Journal | Journal of gastroenterology and hepatology |
| Volume | 2 |
| Issue number | 5 |
| DOIs | |
| State | Published - 1987 |
| Externally published | Yes |
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Keywords
- bleomycin
- dialytic ultrafiltration
- haemofilters
- intraperitoneal chemotherapy
- malignant ascites
- palliation.
ASJC Scopus subject areas
- Hepatology
- Gastroenterology
Cite this
Palliative treatment of malignant ascites by intraperitoneal bleomycin after dialytic ultrafiltration with haemofilter. / LAI, KAR NENG; Leung, Joseph; CHENG, PAUL N.M.; LAI, FERNAND MAC‐MOUNE.
In: Journal of gastroenterology and hepatology, Vol. 2, No. 5, 1987, p. 467-472.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Palliative treatment of malignant ascites by intraperitoneal bleomycin after dialytic ultrafiltration with haemofilter
AU - LAI, KAR NENG
AU - Leung, Joseph
AU - CHENG, PAUL N.M.
AU - LAI, FERNAND MAC‐MOUNE
PY - 1987
Y1 - 1987
N2 - Dialytic ultrafiltration with haemofilter was performed in 16 patients with malignant ascites refractory to treatment with sodium restriction, diuretic and systemic chemotherapy. A continuous flow of ascitic fluid at a rate of 300–400 ml/min through a haemofilter was maintained by a blood pump. The protein‐rich ascitic fluid was re‐infused into the peritoneal cavity with sodium and water removed. An average of 5.2 1 of filtrate was removed over a mean interval of 3.5 h. Bleomycin (60 mg) was administered intraperitoneally following the procedure. Complete response was observed in six patients (37.25%) and partial response occurred in four (25%). The remaining patients showed no response. Complications of the dialytic ultrafiltration procedure and toxicity of intraperitoneal administration of bleomycin were minimal. The technique of dialytic ultrafiltration is simple, safe and cost‐effective and could be used as an adjuvant therapy for intraperitoneal chemotherapy.
AB - Dialytic ultrafiltration with haemofilter was performed in 16 patients with malignant ascites refractory to treatment with sodium restriction, diuretic and systemic chemotherapy. A continuous flow of ascitic fluid at a rate of 300–400 ml/min through a haemofilter was maintained by a blood pump. The protein‐rich ascitic fluid was re‐infused into the peritoneal cavity with sodium and water removed. An average of 5.2 1 of filtrate was removed over a mean interval of 3.5 h. Bleomycin (60 mg) was administered intraperitoneally following the procedure. Complete response was observed in six patients (37.25%) and partial response occurred in four (25%). The remaining patients showed no response. Complications of the dialytic ultrafiltration procedure and toxicity of intraperitoneal administration of bleomycin were minimal. The technique of dialytic ultrafiltration is simple, safe and cost‐effective and could be used as an adjuvant therapy for intraperitoneal chemotherapy.
KW - bleomycin
KW - dialytic ultrafiltration
KW - haemofilters
KW - intraperitoneal chemotherapy
KW - malignant ascites
KW - palliation.
UR - http://www.scopus.com/inward/record.url?scp=85025214995&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85025214995&partnerID=8YFLogxK
U2 - 10.1111/j.1440-1746.1987.tb00191.x
DO - 10.1111/j.1440-1746.1987.tb00191.x
M3 - Article
AN - SCOPUS:85025214995
VL - 2
SP - 467
EP - 472
JO - Journal of Gastroenterology and Hepatology (Australia)
JF - Journal of Gastroenterology and Hepatology (Australia)
SN - 0815-9319
IS - 5
ER -