Palliative treatment of malignant ascites by intraperitoneal bleomycin after dialytic ultrafiltration with haemofilter

KAR NENG LAI, Joseph Leung, PAUL N.M. CHENG, FERNAND MAC‐MOUNE LAI

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Dialytic ultrafiltration with haemofilter was performed in 16 patients with malignant ascites refractory to treatment with sodium restriction, diuretic and systemic chemotherapy. A continuous flow of ascitic fluid at a rate of 300–400 ml/min through a haemofilter was maintained by a blood pump. The protein‐rich ascitic fluid was re‐infused into the peritoneal cavity with sodium and water removed. An average of 5.2 1 of filtrate was removed over a mean interval of 3.5 h. Bleomycin (60 mg) was administered intraperitoneally following the procedure. Complete response was observed in six patients (37.25%) and partial response occurred in four (25%). The remaining patients showed no response. Complications of the dialytic ultrafiltration procedure and toxicity of intraperitoneal administration of bleomycin were minimal. The technique of dialytic ultrafiltration is simple, safe and cost‐effective and could be used as an adjuvant therapy for intraperitoneal chemotherapy.

Original languageEnglish (US)
Pages (from-to)467-472
Number of pages6
JournalJournal of gastroenterology and hepatology
Volume2
Issue number5
DOIs
StatePublished - 1987
Externally publishedYes

Keywords

  • bleomycin
  • dialytic ultrafiltration
  • haemofilters
  • intraperitoneal chemotherapy
  • malignant ascites
  • palliation.

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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