P55, an immunogenic but nonprotective 55-kilodalton Borrelia burgdorferi protein in murine lyme disease

Sunlian Feng, Stephen W Barthold, Sam R. Telford, Erol Fikrig

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Immunization of C3H mice with P55 (previously called S1), a 55-kDa Borrelia burgdorferi antigen that is immunogenic after infection, elicited a strong antibody response but did not protect mice against B. burgdorferi challenge. Mice immunized with a P55 fusion protein in complete Freund's adjuvant developed anti-P55 antibodies, detectable at a titer of 1:10,000 by immunoblotting. To determine if a protective response had been elicited, P55- vaccinated mice were fed upon by ticks infected with B. burgdorferi. The frequency of B. burgdorferi infection was similar in P55-immunized and control mice, and spirochetes were not destroyed within ticks that fed on P55-vaccinated mice. P55 is an immunogenic antigen that does not induce a protective response in the vertebrate or invertebrate host.

Original languageEnglish (US)
Pages (from-to)363-365
Number of pages3
JournalInfection and Immunity
Volume64
Issue number1
StatePublished - 1996
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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