Abstract
Immunization of C3H mice with P55 (previously called S1), a 55-kDa Borrelia burgdorferi antigen that is immunogenic after infection, elicited a strong antibody response but did not protect mice against B. burgdorferi challenge. Mice immunized with a P55 fusion protein in complete Freund's adjuvant developed anti-P55 antibodies, detectable at a titer of 1:10,000 by immunoblotting. To determine if a protective response had been elicited, P55- vaccinated mice were fed upon by ticks infected with B. burgdorferi. The frequency of B. burgdorferi infection was similar in P55-immunized and control mice, and spirochetes were not destroyed within ticks that fed on P55-vaccinated mice. P55 is an immunogenic antigen that does not induce a protective response in the vertebrate or invertebrate host.
Original language | English (US) |
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Pages (from-to) | 363-365 |
Number of pages | 3 |
Journal | Infection and Immunity |
Volume | 64 |
Issue number | 1 |
State | Published - 1996 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology