p53 tumor suppressor and iron homeostasis

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Iron is an essential nutrient for all living organisms and plays a vital role in many fundamental biochemical processes, such as oxygen transport, energy metabolism, and DNA synthesis. Due to its capability to produce free radicals, iron has deleterious effects and thus, its level needs to be tightly controlled in the body. Deregulation of iron metabolism is known to cause diseases, including anemia by iron deficiency and hereditary hemochromatosis by iron overload. Interestingly, dysregulated iron metabolism occurs frequently in tumor cells and contributes to tumorigenesis. In this review, we will discuss the role of p53 tumor suppressor in iron homeostasis.

Original languageEnglish (US)
JournalFEBS Journal
DOIs
StateAccepted/In press - Jan 1 2018

Keywords

  • FDXR
  • iron homeostasis
  • IRP1/2
  • mitochondrial iron homeostasis
  • p53
  • tumor suppression

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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