p53, through p21 (WAF1/CIP1), induces cyclin D1 synthesis

Xinbin Chen, J. Bargonetti, C. Prives

Research output: Contribution to journalArticlepeer-review

163 Scopus citations

Abstract

Cells induced to accumulate the p53 tumor suppressor protein have been shown to arrest in G1. This arrest is characterized by accumulation of the cyclin-dependent kinase inhibitor p21 (WAF1/CIP1) and of underphosphorylated forms of retinoblastoma protein. We show here that accumulation of the wild- type p53 protein in either human or murine cells markedly increases expression of cyclin D1. The induction of cyclin D1 can also be mediated by a target of p53, the p21 (WAF1/CIP1) inhibitor of cyclin-dependent kinases. The relationship between the induction of cyclin D1 and G1 arrest defines a new cellular response to p53.

Original languageEnglish (US)
Pages (from-to)4257-4263
Number of pages7
JournalCancer Research
Volume55
Issue number19
StatePublished - 1995
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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