p53, through p21 (WAF1/CIP1), induces cyclin D1 synthesis

Xinbin Chen, J. Bargonetti, C. Prives

Research output: Contribution to journalArticle

162 Scopus citations

Abstract

Cells induced to accumulate the p53 tumor suppressor protein have been shown to arrest in G1. This arrest is characterized by accumulation of the cyclin-dependent kinase inhibitor p21 (WAF1/CIP1) and of underphosphorylated forms of retinoblastoma protein. We show here that accumulation of the wild- type p53 protein in either human or murine cells markedly increases expression of cyclin D1. The induction of cyclin D1 can also be mediated by a target of p53, the p21 (WAF1/CIP1) inhibitor of cyclin-dependent kinases. The relationship between the induction of cyclin D1 and G1 arrest defines a new cellular response to p53.

Original languageEnglish (US)
Pages (from-to)4257-4263
Number of pages7
JournalCancer Research
Volume55
Issue number19
StatePublished - 1995
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Chen, X., Bargonetti, J., & Prives, C. (1995). p53, through p21 (WAF1/CIP1), induces cyclin D1 synthesis. Cancer Research, 55(19), 4257-4263.