P53 overexpression is associated with bulky tumor and poor local control in T1 glottic cancer

Ashwatha Narayana, Andrew T M Vaughan, Satinder Kathuria, Susan G. Fisher, Scott A. Walter, Sarada P. Reddy

Research output: Contribution to journalArticle

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Abstract

Purpose: To study the role of two possible prognostic factors, p53 and tumor bulk, and their interaction with other tumor and treatment variables in early-stage laryngeal cancer patients treated with curative radiotherapy.Methods: One hundred two patients with T1N0M0 squamous cell carcinoma of the glottic larynx treated with definitive radiotherapy were analyzed. p53 status in pretreatment biopsy specimens was assessed by immunohistochemistry (IHC) using mouse monoclonal antibody DO-7. Tumors were classified as small surface lesions or bulky tumors. All tumor-related and treatment-related variables which might influence the outcome were analyzed. Local control after definitive radiotherapy was the end point of the study.Results: The local control at 5 years for the entire group of patients was 78% (80/102) and 91% (93/102) after surgical salvage. p53 overexpression by IHC was seen in 37% (38/102) of patients. Tumors were classified as small volume in 69 (68%) and bulky in 33 (32%) patients. Five-year local control was 48% for p53-positive patients as compared to 94% for p53-negative patients (p = 0.0001). Tumor bulk was the other important prognostic factor, with 5-year local control of 91% for small tumors and 48% for bulky tumors (p = 0.0001). Patients who had both p53 positivity and bulky tumors did worse, with a 5-year local control of 23% as compared to 92% for all other groups combined (p = 0.0001). Among other variables, only the length of radiation time was of borderline significance.Conclusion: Both p53 overexpression and tumor bulk are independent prognostic factors for local control in early-stage glottic cancer treated with curative radiotherapy. The precise relationship between a genetic event, the p53 mutation, and an observable phenotype expression such as tumor bulk needs to be further defined. Copyright (C) 2000 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)21-26
Number of pages6
JournalInternational Journal of Radiation Oncology Biology Physics
Volume46
Issue number1
DOIs
StatePublished - Jan 1 2000
Externally publishedYes

Fingerprint

Tongue Neoplasms
tumors
cancer
Neoplasms
radiation therapy
Radiotherapy
Immunohistochemistry
larynx
phenotype
Laryngeal Neoplasms
Larynx
mutations
antibodies
Tongue
pretreatment
lesions
mice
Squamous Cell Carcinoma

Keywords

  • Immunohistochemistry
  • Laryngeal cancer
  • p53
  • Radiotherapy
  • Tumor bulk

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

Cite this

P53 overexpression is associated with bulky tumor and poor local control in T1 glottic cancer. / Narayana, Ashwatha; Vaughan, Andrew T M; Kathuria, Satinder; Fisher, Susan G.; Walter, Scott A.; Reddy, Sarada P.

In: International Journal of Radiation Oncology Biology Physics, Vol. 46, No. 1, 01.01.2000, p. 21-26.

Research output: Contribution to journalArticle

Narayana, Ashwatha ; Vaughan, Andrew T M ; Kathuria, Satinder ; Fisher, Susan G. ; Walter, Scott A. ; Reddy, Sarada P. / P53 overexpression is associated with bulky tumor and poor local control in T1 glottic cancer. In: International Journal of Radiation Oncology Biology Physics. 2000 ; Vol. 46, No. 1. pp. 21-26.
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abstract = "Purpose: To study the role of two possible prognostic factors, p53 and tumor bulk, and their interaction with other tumor and treatment variables in early-stage laryngeal cancer patients treated with curative radiotherapy.Methods: One hundred two patients with T1N0M0 squamous cell carcinoma of the glottic larynx treated with definitive radiotherapy were analyzed. p53 status in pretreatment biopsy specimens was assessed by immunohistochemistry (IHC) using mouse monoclonal antibody DO-7. Tumors were classified as small surface lesions or bulky tumors. All tumor-related and treatment-related variables which might influence the outcome were analyzed. Local control after definitive radiotherapy was the end point of the study.Results: The local control at 5 years for the entire group of patients was 78{\%} (80/102) and 91{\%} (93/102) after surgical salvage. p53 overexpression by IHC was seen in 37{\%} (38/102) of patients. Tumors were classified as small volume in 69 (68{\%}) and bulky in 33 (32{\%}) patients. Five-year local control was 48{\%} for p53-positive patients as compared to 94{\%} for p53-negative patients (p = 0.0001). Tumor bulk was the other important prognostic factor, with 5-year local control of 91{\%} for small tumors and 48{\%} for bulky tumors (p = 0.0001). Patients who had both p53 positivity and bulky tumors did worse, with a 5-year local control of 23{\%} as compared to 92{\%} for all other groups combined (p = 0.0001). Among other variables, only the length of radiation time was of borderline significance.Conclusion: Both p53 overexpression and tumor bulk are independent prognostic factors for local control in early-stage glottic cancer treated with curative radiotherapy. The precise relationship between a genetic event, the p53 mutation, and an observable phenotype expression such as tumor bulk needs to be further defined. Copyright (C) 2000 Elsevier Science Inc.",
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T1 - P53 overexpression is associated with bulky tumor and poor local control in T1 glottic cancer

AU - Narayana, Ashwatha

AU - Vaughan, Andrew T M

AU - Kathuria, Satinder

AU - Fisher, Susan G.

AU - Walter, Scott A.

AU - Reddy, Sarada P.

PY - 2000/1/1

Y1 - 2000/1/1

N2 - Purpose: To study the role of two possible prognostic factors, p53 and tumor bulk, and their interaction with other tumor and treatment variables in early-stage laryngeal cancer patients treated with curative radiotherapy.Methods: One hundred two patients with T1N0M0 squamous cell carcinoma of the glottic larynx treated with definitive radiotherapy were analyzed. p53 status in pretreatment biopsy specimens was assessed by immunohistochemistry (IHC) using mouse monoclonal antibody DO-7. Tumors were classified as small surface lesions or bulky tumors. All tumor-related and treatment-related variables which might influence the outcome were analyzed. Local control after definitive radiotherapy was the end point of the study.Results: The local control at 5 years for the entire group of patients was 78% (80/102) and 91% (93/102) after surgical salvage. p53 overexpression by IHC was seen in 37% (38/102) of patients. Tumors were classified as small volume in 69 (68%) and bulky in 33 (32%) patients. Five-year local control was 48% for p53-positive patients as compared to 94% for p53-negative patients (p = 0.0001). Tumor bulk was the other important prognostic factor, with 5-year local control of 91% for small tumors and 48% for bulky tumors (p = 0.0001). Patients who had both p53 positivity and bulky tumors did worse, with a 5-year local control of 23% as compared to 92% for all other groups combined (p = 0.0001). Among other variables, only the length of radiation time was of borderline significance.Conclusion: Both p53 overexpression and tumor bulk are independent prognostic factors for local control in early-stage glottic cancer treated with curative radiotherapy. The precise relationship between a genetic event, the p53 mutation, and an observable phenotype expression such as tumor bulk needs to be further defined. Copyright (C) 2000 Elsevier Science Inc.

AB - Purpose: To study the role of two possible prognostic factors, p53 and tumor bulk, and their interaction with other tumor and treatment variables in early-stage laryngeal cancer patients treated with curative radiotherapy.Methods: One hundred two patients with T1N0M0 squamous cell carcinoma of the glottic larynx treated with definitive radiotherapy were analyzed. p53 status in pretreatment biopsy specimens was assessed by immunohistochemistry (IHC) using mouse monoclonal antibody DO-7. Tumors were classified as small surface lesions or bulky tumors. All tumor-related and treatment-related variables which might influence the outcome were analyzed. Local control after definitive radiotherapy was the end point of the study.Results: The local control at 5 years for the entire group of patients was 78% (80/102) and 91% (93/102) after surgical salvage. p53 overexpression by IHC was seen in 37% (38/102) of patients. Tumors were classified as small volume in 69 (68%) and bulky in 33 (32%) patients. Five-year local control was 48% for p53-positive patients as compared to 94% for p53-negative patients (p = 0.0001). Tumor bulk was the other important prognostic factor, with 5-year local control of 91% for small tumors and 48% for bulky tumors (p = 0.0001). Patients who had both p53 positivity and bulky tumors did worse, with a 5-year local control of 23% as compared to 92% for all other groups combined (p = 0.0001). Among other variables, only the length of radiation time was of borderline significance.Conclusion: Both p53 overexpression and tumor bulk are independent prognostic factors for local control in early-stage glottic cancer treated with curative radiotherapy. The precise relationship between a genetic event, the p53 mutation, and an observable phenotype expression such as tumor bulk needs to be further defined. Copyright (C) 2000 Elsevier Science Inc.

KW - Immunohistochemistry

KW - Laryngeal cancer

KW - p53

KW - Radiotherapy

KW - Tumor bulk

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