p53 modulation of the DNA damage response

E. Scott Helton, Xinbin Chen

Research output: Contribution to journalArticle

184 Scopus citations

Abstract

The tumor suppressor p53 plays a central role in the DNA damage response. After exposure to genotoxic stress, p53 can both positively and negatively regulate cell fate. Initially, p53 promotes cell survival by inducing cell cycle arrest, DNA repair, and other pro-survival pathways. However, when cells accumulate DNA damage or demonstrate aberrant growth, p53 can direct the elimination of damaged cells. In this review, we will discuss the transcriptional-dependent and -independent roles of p53 in regulating the DNA damage response.

Original languageEnglish (US)
Pages (from-to)883-896
Number of pages14
JournalJournal of Cellular Biochemistry
Volume100
Issue number4
DOIs
StatePublished - Mar 1 2007
Externally publishedYes

Keywords

  • Cell cycle
  • DNA damage response
  • DNA repair
  • p53
  • Pro-survival

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

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