p53 Autoantibodies

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The p53 molecule is a tumor suppressor that prevents the outgrowth of aberrant cells by inducing cell cycle arrest, DNA repair, or programmed cell death. On healthy cells, p53 is barely detectable. In contrast, most tumor cells manifest an accumulation of p53 protein. Tumor-associated p53 accumulation may activate p53 autoimmunity; thus, autoantibodies to p53 can serve as markers for established or even incipient tumors. However, p53 accumulation may also occur in nontumor cells under various forms of stress; thus it has become clear that the occurrence of p53 antibodies is not restricted to cancer but can also happen in a variety of autoimmune diseases. Moreover, the p53 antibodies found in autoimmune disease appear to be associated with autoantibodies to deoxyribonucleic acid (DNA). The pathogenic relevance of p53 autoantibodies is currently unclear.

Original languageEnglish (US)
Title of host publicationAutoantibodies: Third Edition
PublisherElsevier B.V.
Pages289-294
Number of pages6
ISBN (Print)9780444563781
DOIs
StatePublished - Dec 2013

Keywords

  • Anti-DNA antibodies
  • Autoimmune hepatitis
  • Autoimmunity
  • Rheumatoid arthritis
  • Systemic lupus erythematosus
  • Tumor suppressor

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

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  • Cite this

    Bowlus, C. (2013). p53 Autoantibodies. In Autoantibodies: Third Edition (pp. 289-294). Elsevier B.V.. https://doi.org/10.1016/B978-0-444-56378-1.00034-4