P2 protein-induced experimental allergic neuritis. An ultrastructural study

Kyoko Saida, Takahiko Saida, David E Pleasure, Hiroshi Nishitani

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Experimental allergic neuritis (EAN) was induced in 2 groups of inbred Lewis rats by sensitization with P2 protein and peripheral nervous system (PNS) myelin, both purified from bovine intradural roots. Light- and electron-microscopic study of P2-induced EAN revealed demyelinative lesions in spinal ganglia and root nerves and less frequently in peripheral nerves and root entry zones. Both small and large myelinated fibers were demyelinated, contradictory to the reported selective binding of anti-P2 antibodies to myelin of large fibers. The early lesions were characterised by perivenular lymphocytic infiltration, and subsequent "dissolution" of myelin sheath was associated with invasion of phagocytic cells. The distribution of demyelinative lesions and patterns of demyelination resembled those of PNS myelin-induced EAN except that the disease was milder and dissolution of myelin and intramyelinic edema were more frequently found in P2-induced EAN. The abundance of demyelination in P2-induced EAN strikes contrast to the scarcity of myelin change in experimental allergic encephalomyelitis (EAE) induced by myelin basic protein immunization.

Original languageEnglish (US)
Pages (from-to)77-93
Number of pages17
JournalJournal of the Neurological Sciences
Volume62
Issue number1-3
DOIs
StatePublished - 1983
Externally publishedYes

Fingerprint

Experimental Autoimmune Neuritis
Myelin Sheath
Proteins
Peripheral Nervous System
Demyelinating Diseases
Inbred Lew Rats
Myelin Basic Protein
Autoimmune Experimental Encephalomyelitis
Spinal Nerve Roots
Spinal Ganglia
Phagocytes
Peripheral Nerves
Anti-Idiotypic Antibodies
Immunization
Edema
Electrons
Light

Keywords

  • Demyelination
  • Experimental allergic encephalomyelitis
  • Experimental allergic neuritis
  • Guillain-Barré syndrome
  • Myelin basic protein P2 protein

ASJC Scopus subject areas

  • Aging
  • Clinical Neurology
  • Surgery
  • Neuroscience(all)
  • Developmental Neuroscience
  • Neurology

Cite this

P2 protein-induced experimental allergic neuritis. An ultrastructural study. / Saida, Kyoko; Saida, Takahiko; Pleasure, David E; Nishitani, Hiroshi.

In: Journal of the Neurological Sciences, Vol. 62, No. 1-3, 1983, p. 77-93.

Research output: Contribution to journalArticle

Saida, Kyoko ; Saida, Takahiko ; Pleasure, David E ; Nishitani, Hiroshi. / P2 protein-induced experimental allergic neuritis. An ultrastructural study. In: Journal of the Neurological Sciences. 1983 ; Vol. 62, No. 1-3. pp. 77-93.
@article{9c5be9f1e8224b0e88fef7c39d4fdae9,
title = "P2 protein-induced experimental allergic neuritis. An ultrastructural study",
abstract = "Experimental allergic neuritis (EAN) was induced in 2 groups of inbred Lewis rats by sensitization with P2 protein and peripheral nervous system (PNS) myelin, both purified from bovine intradural roots. Light- and electron-microscopic study of P2-induced EAN revealed demyelinative lesions in spinal ganglia and root nerves and less frequently in peripheral nerves and root entry zones. Both small and large myelinated fibers were demyelinated, contradictory to the reported selective binding of anti-P2 antibodies to myelin of large fibers. The early lesions were characterised by perivenular lymphocytic infiltration, and subsequent {"}dissolution{"} of myelin sheath was associated with invasion of phagocytic cells. The distribution of demyelinative lesions and patterns of demyelination resembled those of PNS myelin-induced EAN except that the disease was milder and dissolution of myelin and intramyelinic edema were more frequently found in P2-induced EAN. The abundance of demyelination in P2-induced EAN strikes contrast to the scarcity of myelin change in experimental allergic encephalomyelitis (EAE) induced by myelin basic protein immunization.",
keywords = "Demyelination, Experimental allergic encephalomyelitis, Experimental allergic neuritis, Guillain-Barr{\'e} syndrome, Myelin basic protein P2 protein",
author = "Kyoko Saida and Takahiko Saida and Pleasure, {David E} and Hiroshi Nishitani",
year = "1983",
doi = "10.1016/0022-510X(83)90191-0",
language = "English (US)",
volume = "62",
pages = "77--93",
journal = "Journal of the Neurological Sciences",
issn = "0022-510X",
publisher = "Elsevier",
number = "1-3",

}

TY - JOUR

T1 - P2 protein-induced experimental allergic neuritis. An ultrastructural study

AU - Saida, Kyoko

AU - Saida, Takahiko

AU - Pleasure, David E

AU - Nishitani, Hiroshi

PY - 1983

Y1 - 1983

N2 - Experimental allergic neuritis (EAN) was induced in 2 groups of inbred Lewis rats by sensitization with P2 protein and peripheral nervous system (PNS) myelin, both purified from bovine intradural roots. Light- and electron-microscopic study of P2-induced EAN revealed demyelinative lesions in spinal ganglia and root nerves and less frequently in peripheral nerves and root entry zones. Both small and large myelinated fibers were demyelinated, contradictory to the reported selective binding of anti-P2 antibodies to myelin of large fibers. The early lesions were characterised by perivenular lymphocytic infiltration, and subsequent "dissolution" of myelin sheath was associated with invasion of phagocytic cells. The distribution of demyelinative lesions and patterns of demyelination resembled those of PNS myelin-induced EAN except that the disease was milder and dissolution of myelin and intramyelinic edema were more frequently found in P2-induced EAN. The abundance of demyelination in P2-induced EAN strikes contrast to the scarcity of myelin change in experimental allergic encephalomyelitis (EAE) induced by myelin basic protein immunization.

AB - Experimental allergic neuritis (EAN) was induced in 2 groups of inbred Lewis rats by sensitization with P2 protein and peripheral nervous system (PNS) myelin, both purified from bovine intradural roots. Light- and electron-microscopic study of P2-induced EAN revealed demyelinative lesions in spinal ganglia and root nerves and less frequently in peripheral nerves and root entry zones. Both small and large myelinated fibers were demyelinated, contradictory to the reported selective binding of anti-P2 antibodies to myelin of large fibers. The early lesions were characterised by perivenular lymphocytic infiltration, and subsequent "dissolution" of myelin sheath was associated with invasion of phagocytic cells. The distribution of demyelinative lesions and patterns of demyelination resembled those of PNS myelin-induced EAN except that the disease was milder and dissolution of myelin and intramyelinic edema were more frequently found in P2-induced EAN. The abundance of demyelination in P2-induced EAN strikes contrast to the scarcity of myelin change in experimental allergic encephalomyelitis (EAE) induced by myelin basic protein immunization.

KW - Demyelination

KW - Experimental allergic encephalomyelitis

KW - Experimental allergic neuritis

KW - Guillain-Barré syndrome

KW - Myelin basic protein P2 protein

UR - http://www.scopus.com/inward/record.url?scp=0021077023&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021077023&partnerID=8YFLogxK

U2 - 10.1016/0022-510X(83)90191-0

DO - 10.1016/0022-510X(83)90191-0

M3 - Article

C2 - 6199467

AN - SCOPUS:0021077023

VL - 62

SP - 77

EP - 93

JO - Journal of the Neurological Sciences

JF - Journal of the Neurological Sciences

SN - 0022-510X

IS - 1-3

ER -