Ozone-induced accelerated lung clearance of 99mTc-DTPA aerosol in conscious sheep

William J. Hornof, Edward S Schelegle, Michael Kammerman, Robert A. Gunther, Paul E. Fisher, Carroll E Cross

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

This study was initiated to determine the rate and characteristics of 99mTc-DTPA clearance from the lungs of unanesthetized sheep exposed to varying concentrations of O3 for 4 h in a whole-body exposure chamber. Four sheep exposed to 1 ppm O3 had a monoexponential T50 of 274 ± 81 min (SD), not significantly different from sham exposures (316±150); 5 sheep exposed to 2 ppm had a T50 of 234 ± 101 min, not significantly different from sham exposures (263±107 min); 3 sheep exposed to 4 ppm showed a T50 of 66 ± 19 min, markedly different from sham exposures (364 ± 131 min). Five additional unanesthetized sheep exposed to 2 ppm for 4 h via a nasotracheal tube had a T50 of 192 ± 55 min, significantly different from sham exposures (300 ± 96 min). The results show that the effect of oxidant pollutants on the permeability of alveolobronchiolar epithelium may be assessed in conscious sheep.

Original languageEnglish (US)
Pages (from-to)277-290
Number of pages14
JournalRespiration Physiology
Volume77
Issue number3
DOIs
StatePublished - 1989

Keywords

  • Tc-DTPA
  • Bronchoalveolar clearance
  • Ozone
  • Respiratory epithelial permeability
  • Sheep

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine

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