Ozone and Oxygen Toxicity

J. A. Last; Dallas Melvin Hyde; E. S. Schelegle

doi:10.1016/B978-0-08-046884-6.00913-1

Ozone and Oxygen Toxicity

J. A. Last, Dallas Melvin Hyde, E. S. Schelegle

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Ozone is a ubiquitous air pollutant, especially in summer months due to the need for ultraviolet radiation for its atmospheric biosynthesis from its precursors, nitrogen oxides and volatile organic compounds. This chapter discusses the toxicological, epidemiological, and mechanistic evidence that concentrations of ozone at, or near, ambient levels are capable of causing acute and chronic lung injury and disease. The underlying cellular mechanisms of lung injury and repair are briefly discussed. Key studies that have informed Environmental Protection Agency's (EPA) risk assessment and standard setting are presented and analyzed.

Original language	English (US)
Title of host publication	Respiratory Toxicology
Publisher	Elsevier Inc.
Pages	261-275
Number of pages	15
Volume	8
ISBN (Print)	9780080468686
DOIs	https://doi.org/10.1016/B978-0-08-046884-6.00913-1
State	Published - Aug 12 2010

ASJC Scopus subject areas

Medicine(all)

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AU - Last, J. A.

AU - Hyde, Dallas Melvin

AU - Schelegle, E. S.

PY - 2010/8/12

Y1 - 2010/8/12

N2 - Ozone is a ubiquitous air pollutant, especially in summer months due to the need for ultraviolet radiation for its atmospheric biosynthesis from its precursors, nitrogen oxides and volatile organic compounds. This chapter discusses the toxicological, epidemiological, and mechanistic evidence that concentrations of ozone at, or near, ambient levels are capable of causing acute and chronic lung injury and disease. The underlying cellular mechanisms of lung injury and repair are briefly discussed. Key studies that have informed Environmental Protection Agency's (EPA) risk assessment and standard setting are presented and analyzed.

AB - Ozone is a ubiquitous air pollutant, especially in summer months due to the need for ultraviolet radiation for its atmospheric biosynthesis from its precursors, nitrogen oxides and volatile organic compounds. This chapter discusses the toxicological, epidemiological, and mechanistic evidence that concentrations of ozone at, or near, ambient levels are capable of causing acute and chronic lung injury and disease. The underlying cellular mechanisms of lung injury and repair are briefly discussed. Key studies that have informed Environmental Protection Agency's (EPA) risk assessment and standard setting are presented and analyzed.

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M3 - Chapter

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SN - 9780080468686

VL - 8

SP - 261

EP - 275

BT - Respiratory Toxicology

PB - Elsevier Inc.

ER -

Ozone and Oxygen Toxicity

Abstract

ASJC Scopus subject areas

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