Ozone and Oxygen Toxicity

J. A. Last, Dallas Melvin Hyde, E. S. Schelegle

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Ozone is a ubiquitous air pollutant, especially in summer months due to the need for ultraviolet radiation for its atmospheric biosynthesis from its precursors, nitrogen oxides and volatile organic compounds. This chapter discusses the toxicological, epidemiological, and mechanistic evidence that concentrations of ozone at, or near, ambient levels are capable of causing acute and chronic lung injury and disease. The underlying cellular mechanisms of lung injury and repair are briefly discussed. Key studies that have informed Environmental Protection Agency's (EPA) risk assessment and standard setting are presented and analyzed.

Original languageEnglish (US)
Title of host publicationRespiratory Toxicology
PublisherElsevier Inc.
Number of pages15
ISBN (Print)9780080468686
StatePublished - Aug 12 2010

ASJC Scopus subject areas

  • Medicine(all)


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