Oxytocin binding in the uterus of the cycling mare

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Excised uteri from 22 reproductively sound cycling mares were divided into 4 groups according to the stage of the estrous cycle of each mare and analyzed for changes in the number of oxytocin binding sites and their affinity. The number of binding sites in the myometrial layer of the uterus was greater (P<.01) than in the endometrial layer, with an approximate 3-fold difference. The number of oxytocin binding sites was greater (P<.05) during Days 14–17, post-ovulation, in both the endometrial and myometrial uterine tissue samples than during Days 2–5, Days 6–13 or Days 18-1. The affinity constants were greater (P<.01) in the endometrium than myometrium, but no difference (P>.05) was found in the four groups throughout the estrous cycle for endometrium or myometrium. In view of the known hormonal events occurring in the estrous cycle of the mare, along with in vitro data demonstrated with other species and the mare, the increase in oxytocin binding sites during Days 14–17 may enhance the production of the luteolytic hormone, prostaglandin (PFG). This may be due to the increasing concentration of estradiol, which has a stimulatory effect on estrogen and oxytocin binding sites and thus promotes increased PGF synthesis.

Original languageEnglish (US)
Pages (from-to)114-119
Number of pages6
JournalJournal of Equine Veterinary Science
Volume6
Issue number3
DOIs
StatePublished - Jan 1 1986

Fingerprint

oxytocin
Oxytocin
uterus
mares
Uterus
Estrous Cycle
binding sites
Binding Sites
estrous cycle
myometrium
Dinoprost
Myometrium
endometrium
Endometrium
prostaglandins
estrogens
Prostaglandins
estradiol
Estradiol
Estrogens

ASJC Scopus subject areas

  • Equine

Cite this

Oxytocin binding in the uterus of the cycling mare. / Stull, Carolyn.

In: Journal of Equine Veterinary Science, Vol. 6, No. 3, 01.01.1986, p. 114-119.

Research output: Contribution to journalArticle

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