Oxytocin and cholecystokinin induced grooming behavior in the ventral tegmentum of the rat

Maria Th Kaltwasser; Jacqueline Crawley

doi:10.1016/0006-8993(87)90418-5

Oxytocin and cholecystokinin induced grooming behavior in the ventral tegmentum of the rat

Maria Th Kaltwasser, Jacqueline Crawley

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Oxytocin (OXY) and cholecystokinin (CCK) coexist in neurons of the supraoptic nucleus and the paraventricular nucleus of the hypothalamus of the rat (Cell Tissue Res., 221 (1981) 227-231). Behavioral analysis of one possible terminal field of the OXY-CCK coexistence, the caudal region of the mesencephalic ventral tegmentum, was undertaken to investigate the functional significance of this coexistence. Both OXY and CCK were found to induce grooming behaviors when microinjected into the ventral tegmental area (VTA) of awake rats. Combinations of one low and one higher dose of OXY and CCK yielded grooming scores which were not significantly different from grooming scores induced by each peptide alone. In this case of putative coexistence of two peptides without a 'classical' neurotransmitter, each peptide appears to have a behavioral function, and the interaction between the two peptides may be competitive.

Original language	English (US)
Pages (from-to)	1-7
Number of pages	7
Journal	Brain Research
Volume	426
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(87)90418-5
State	Published - Nov 17 1987
Externally published	Yes

Keywords

Cholecystokinin
Coexistence
Grooming behavior
Oxytocin

ASJC Scopus subject areas

Developmental Biology
Molecular Biology
Clinical Neurology
Neuroscience(all)

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title = "Oxytocin and cholecystokinin induced grooming behavior in the ventral tegmentum of the rat",

abstract = "Oxytocin (OXY) and cholecystokinin (CCK) coexist in neurons of the supraoptic nucleus and the paraventricular nucleus of the hypothalamus of the rat (Cell Tissue Res., 221 (1981) 227-231). Behavioral analysis of one possible terminal field of the OXY-CCK coexistence, the caudal region of the mesencephalic ventral tegmentum, was undertaken to investigate the functional significance of this coexistence. Both OXY and CCK were found to induce grooming behaviors when microinjected into the ventral tegmental area (VTA) of awake rats. Combinations of one low and one higher dose of OXY and CCK yielded grooming scores which were not significantly different from grooming scores induced by each peptide alone. In this case of putative coexistence of two peptides without a 'classical' neurotransmitter, each peptide appears to have a behavioral function, and the interaction between the two peptides may be competitive.",

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T1 - Oxytocin and cholecystokinin induced grooming behavior in the ventral tegmentum of the rat

AU - Kaltwasser, Maria Th

AU - Crawley, Jacqueline

PY - 1987/11/17

Y1 - 1987/11/17

N2 - Oxytocin (OXY) and cholecystokinin (CCK) coexist in neurons of the supraoptic nucleus and the paraventricular nucleus of the hypothalamus of the rat (Cell Tissue Res., 221 (1981) 227-231). Behavioral analysis of one possible terminal field of the OXY-CCK coexistence, the caudal region of the mesencephalic ventral tegmentum, was undertaken to investigate the functional significance of this coexistence. Both OXY and CCK were found to induce grooming behaviors when microinjected into the ventral tegmental area (VTA) of awake rats. Combinations of one low and one higher dose of OXY and CCK yielded grooming scores which were not significantly different from grooming scores induced by each peptide alone. In this case of putative coexistence of two peptides without a 'classical' neurotransmitter, each peptide appears to have a behavioral function, and the interaction between the two peptides may be competitive.

AB - Oxytocin (OXY) and cholecystokinin (CCK) coexist in neurons of the supraoptic nucleus and the paraventricular nucleus of the hypothalamus of the rat (Cell Tissue Res., 221 (1981) 227-231). Behavioral analysis of one possible terminal field of the OXY-CCK coexistence, the caudal region of the mesencephalic ventral tegmentum, was undertaken to investigate the functional significance of this coexistence. Both OXY and CCK were found to induce grooming behaviors when microinjected into the ventral tegmental area (VTA) of awake rats. Combinations of one low and one higher dose of OXY and CCK yielded grooming scores which were not significantly different from grooming scores induced by each peptide alone. In this case of putative coexistence of two peptides without a 'classical' neurotransmitter, each peptide appears to have a behavioral function, and the interaction between the two peptides may be competitive.

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KW - Coexistence

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Oxytocin and cholecystokinin induced grooming behavior in the ventral tegmentum of the rat

Abstract

Keywords

ASJC Scopus subject areas

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