Oxytetracycline hydrochloride in the horse: serum, synovial, peritoneal and urine concentrations after single dose intravenous administration.

M. P. Brown, Susan M Stover, R. H. Kelly, Thomas B Farver, H. D. Knight

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Six adult mares were given a single intravenous injection of oxytetracycline HCl (50 mg/ml) at a dosage of 5 mg/kg. Serum, synovial fluid, peritoneal fluid, and urine oxytetracycline concentrations were measured serially over a 48-h period. The highest measured serum oxytetracycline concentration was 8.01 mcg/ml at 1/2 h. Oxytetracycline was detected in synovial fluid and peritoneal fluid, which obtained mean peak oxytetracycline concentrations of 4.43 mcg/ml and 4.20 mcg/ml, at 1/2 h and 1 h, respectively. These concentrations steadily declined in parallel with serum concentrations and were not measurable at 48 h. Urine oxytetracycline concentration was relatively high, with a peak concentration of 1565.2 mcg/ml at 1/2 h after drug administration.

Original languageEnglish (US)
Pages (from-to)7-10
Number of pages4
JournalJournal of Veterinary Pharmacology and Therapeutics
Volume4
Issue number1
StatePublished - Mar 1981

ASJC Scopus subject areas

  • Pharmacology
  • veterinary(all)

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