Oxytetracycline hydrochloride in the horse

serum, synovial, peritoneal and urine concentrations after single dose intravenous administration.

M. P. Brown, Susan M Stover, R. H. Kelly, Thomas B Farver, H. D. Knight

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Six adult mares were given a single intravenous injection of oxytetracycline HCl (50 mg/ml) at a dosage of 5 mg/kg. Serum, synovial fluid, peritoneal fluid, and urine oxytetracycline concentrations were measured serially over a 48-h period. The highest measured serum oxytetracycline concentration was 8.01 mcg/ml at 1/2 h. Oxytetracycline was detected in synovial fluid and peritoneal fluid, which obtained mean peak oxytetracycline concentrations of 4.43 mcg/ml and 4.20 mcg/ml, at 1/2 h and 1 h, respectively. These concentrations steadily declined in parallel with serum concentrations and were not measurable at 48 h. Urine oxytetracycline concentration was relatively high, with a peak concentration of 1565.2 mcg/ml at 1/2 h after drug administration.

Original languageEnglish (US)
Pages (from-to)7-10
Number of pages4
JournalJournal of Veterinary Pharmacology and Therapeutics
Volume4
Issue number1
StatePublished - Mar 1981

Fingerprint

Oxytetracycline
oxytetracycline
intravenous injection
Intravenous Administration
Horses
urine
Urine
horses
dosage
Serum
synovial fluid
Ascitic Fluid
Synovial Fluid
Intravenous Injections
mares
drugs
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology
  • veterinary(all)

Cite this

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abstract = "Six adult mares were given a single intravenous injection of oxytetracycline HCl (50 mg/ml) at a dosage of 5 mg/kg. Serum, synovial fluid, peritoneal fluid, and urine oxytetracycline concentrations were measured serially over a 48-h period. The highest measured serum oxytetracycline concentration was 8.01 mcg/ml at 1/2 h. Oxytetracycline was detected in synovial fluid and peritoneal fluid, which obtained mean peak oxytetracycline concentrations of 4.43 mcg/ml and 4.20 mcg/ml, at 1/2 h and 1 h, respectively. These concentrations steadily declined in parallel with serum concentrations and were not measurable at 48 h. Urine oxytetracycline concentration was relatively high, with a peak concentration of 1565.2 mcg/ml at 1/2 h after drug administration.",
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T1 - Oxytetracycline hydrochloride in the horse

T2 - serum, synovial, peritoneal and urine concentrations after single dose intravenous administration.

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AU - Stover, Susan M

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AU - Farver, Thomas B

AU - Knight, H. D.

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