Oxygenation during perfluorocarbon associated gas exchange in normal and abnormal lungs

L. J. Hernan, B. P. Fuhrman, M. C. Papo, C. L. Leach, A. E. Thompson, F. D. Nesti, N. Salman, D. M. Steinhorn, W. Novotny, P. Paczan, B. Burak, M. Rath

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Perfluorocarbon-associated gas exchange (PAGE) has been proposed for the treatment of lung diseases characterized by high alveolar surface tension. Perflubron (perfluorooctyl bromide, LiquiVent®, Alliance Pharmaceutical Corp.) is a high purity medical grade perfluorocarbon suitable for PAGE. We studied PAGE using perflubron in normal piglets and in animal models of pulmonary disease (meconium aspiration syndrome, oleic acid infusion and gastric acid aspiration as models of ARDS, and neonatal respiratory distress syndrome). All animals were studied under anesthesia. PAGE was instituted by intratracheal instillation of a volume of perflubron (generally 30 ml/kg) that approximates a normal functional residual capacity of the lung. Arterial blood gases were measured at 15 minute intervals. FiO2 during PAGE was 1.0. In normal piglets, PaO2 fell from 543 torr (during conventional gas breathing) to 363 torr (during PAGE). However, in models of lung disease, PAGE significantly enhanced PaO2.

Original languageEnglish (US)
Pages (from-to)1377-1380
Number of pages4
JournalArtificial Cells, Blood Substitutes, and Immobilization Biotechnology
Volume22
Issue number4
StatePublished - 1994
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Biomedical Engineering
  • Biomaterials
  • Hematology

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    Hernan, L. J., Fuhrman, B. P., Papo, M. C., Leach, C. L., Thompson, A. E., Nesti, F. D., Salman, N., Steinhorn, D. M., Novotny, W., Paczan, P., Burak, B., & Rath, M. (1994). Oxygenation during perfluorocarbon associated gas exchange in normal and abnormal lungs. Artificial Cells, Blood Substitutes, and Immobilization Biotechnology, 22(4), 1377-1380.