Abstract
Toxic oxygen free radicals have been implicated as important pathologic mediators in many clinical disorders. We discuss the chemistry of oxygen radical production and the roles of iron and of various antioxidants as well as the diseases that have received active attention in oxyradical research. Particular attention is focused on cigarette smoke oxidants, ischemia-reperfusion-induced radical production, carcinogenesis, and aging. Such research may well provide a firm foundation for therapeutic breakthroughs.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 526-545 |
| Number of pages | 20 |
| Journal | Annals of Internal Medicine |
| Volume | 107 |
| Issue number | 4 |
| State | Published - 1987 |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Oxygen radicals and human disease. Davis conference. / Cross, Carroll E; Halliwell, B.; Borish, E. T.; Pryor, W. A.; Ames, B. N.; Saul, R. L.; McCord, J. M.; Harman, D.
In: Annals of Internal Medicine, Vol. 107, No. 4, 1987, p. 526-545.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Oxygen radicals and human disease. Davis conference
AU - Cross, Carroll E
AU - Halliwell, B.
AU - Borish, E. T.
AU - Pryor, W. A.
AU - Ames, B. N.
AU - Saul, R. L.
AU - McCord, J. M.
AU - Harman, D.
PY - 1987
Y1 - 1987
N2 - Toxic oxygen free radicals have been implicated as important pathologic mediators in many clinical disorders. We discuss the chemistry of oxygen radical production and the roles of iron and of various antioxidants as well as the diseases that have received active attention in oxyradical research. Particular attention is focused on cigarette smoke oxidants, ischemia-reperfusion-induced radical production, carcinogenesis, and aging. Such research may well provide a firm foundation for therapeutic breakthroughs.
AB - Toxic oxygen free radicals have been implicated as important pathologic mediators in many clinical disorders. We discuss the chemistry of oxygen radical production and the roles of iron and of various antioxidants as well as the diseases that have received active attention in oxyradical research. Particular attention is focused on cigarette smoke oxidants, ischemia-reperfusion-induced radical production, carcinogenesis, and aging. Such research may well provide a firm foundation for therapeutic breakthroughs.
UR - http://www.scopus.com/inward/record.url?scp=0023229496&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023229496&partnerID=8YFLogxK
M3 - Article
C2 - 3307585
AN - SCOPUS:0023229496
VL - 107
SP - 526
EP - 545
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
SN - 0003-4819
IS - 4
ER -