Oxygen radicals and human disease. Davis conference

Carroll E Cross, B. Halliwell, E. T. Borish, W. A. Pryor, B. N. Ames, R. L. Saul, J. M. McCord, D. Harman

Research output: Contribution to journalArticlepeer-review

1445 Scopus citations

Abstract

Toxic oxygen free radicals have been implicated as important pathologic mediators in many clinical disorders. We discuss the chemistry of oxygen radical production and the roles of iron and of various antioxidants as well as the diseases that have received active attention in oxyradical research. Particular attention is focused on cigarette smoke oxidants, ischemia-reperfusion-induced radical production, carcinogenesis, and aging. Such research may well provide a firm foundation for therapeutic breakthroughs.

Original languageEnglish (US)
Pages (from-to)526-545
Number of pages20
JournalAnnals of Internal Medicine
Volume107
Issue number4
StatePublished - 1987

ASJC Scopus subject areas

  • Medicine(all)

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