Oxidized low-density lipoprotein and atherosclerosis

S. Devaraj, I. Jialal

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

Atherosclerosis is the leading cause of morbidity and mortality in western society. The most important risk factors for atherosclerosis include smoking, hypertension, dyslipidemia, diabetes and a family history of premature atherosclerosis. Several studies indicate that an increased plasma low density lipoprotein (LDL) cholesterol constitutes a major risk factor for atherosclerosis. Many data support a proatherogenic role for oxidized LDL and its in vivo existence. The oxidative susceptibility of LDL is increased with established cardiovascular risk factors, such as diabetes, smoking and dyslipidemia. Supplementation with antioxidants such as ascorbate and alpha-tocopherol can decrease LDL oxidation as well as cardiovascular mortality and thus shows promise in the prevention of atherosclerosis.

Original languageEnglish (US)
Pages (from-to)178-184
Number of pages7
JournalInternational Journal of Clinical & Laboratory Research
Volume26
Issue number3
DOIs
StatePublished - Sep 1996
Externally publishedYes

Keywords

  • Alpha-tocopherol
  • Ascorbate
  • Atherosclerosis
  • Lipid peroxidation
  • Low density lipoprotein

ASJC Scopus subject areas

  • Clinical Biochemistry

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