Oxidatively Modified LDL and Atherosclerosis: An Evolving Plausible Scenario

I. Jialal, Cindy J. Fuller

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Much evidence has accumulated that implicates the oxidative modification of low-density lipoprotein (LDL) in the early stages of atherogenesis. The antioxidant nutrients alpha-tocopherol, ascorbic acid, and betacarotene have been shown to inhibit in vitro LDL oxidation. In addition, they have been shown to increase the resistance of LDL to oxidation when given to animals and humans. Because plasma levels of these nutrients can be increased by dietary supplementation with minimal side effects, they may show promise in the prevention of coronary artery disease.

Original languageEnglish (US)
Pages (from-to)341-353
Number of pages13
JournalCritical Reviews in Food Science and Nutrition
Volume36
Issue number4
StatePublished - 1996
Externally publishedYes

Keywords

  • Alpha-tocopherol
  • Ascorbic acid
  • Atherosclerosis
  • Beta-carotene
  • Low-density lipoprotein
  • Probucol

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

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