Oxidative stress in Alzheimer's disease

Mark A. Smith, Catherine Rottkamp, Akihiko Nunomura, Arun K. Raina, George Perry

Research output: Contribution to journalReview article

599 Scopus citations

Abstract

Oxidative balance is emerging as an important issue in understanding the pathogenesis of Alzheimer's disease. Examination of Alzheimer's disease brain has demonstrated a great deal of oxidative damage, associated with both hallmark pathologies (senile plaques and neurofibrillary tangles) as well as in normal appearing pyramidal neurons. While this suggests that oxidative stress is a proximal event in Alzheimer's disease pathogenesis, the mechanisms by which redox balance is altered in the disease remains elusive. Determining which of the proposed sources of free radicals, which include mitochondrial dysfunction, amyloid-β-mediated processes, transition metal accumulation and genetic factors like apolipoprotein E and presenilins, is responsible for redox imbalance will lead to a better understanding of Alzheimer's disease pathogenesis and novel therapeutic approaches. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)139-144
Number of pages6
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Volume1502
Issue number1
DOIs
StatePublished - Jul 26 2000
Externally publishedYes

Keywords

  • Amyloid-β
  • Antioxidant
  • Free radical
  • Mitochondria
  • Redox imbalance
  • Transition metal

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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