Abstract
Recent evidence in the field of Alzheimer disease research has highlighted the importance of oxidative processes in its pathogenesis. Examination of cellular changes shows that oxidative stress is an event that precedes the appearance of neurofibrillary tangles, one of the hallmark pathologies of the disease. Although it is still unclear what the initial source of the oxidative stress is in Alzheimer disease, it is likely that the process is highly dependent on the presence of redox-active transition metals, such as iron and copper. Because of the proximal role that oxidative stress mechanisms seem to play in the pathogenesis of Alzheimer disease, further investigation in this realm may lead to novel therapeutic strategies.
| Original language | English (US) |
|---|---|
| Journal | Alzheimer Disease and Associated Disorders |
| Volume | 14 |
| Issue number | SUPPL. 1 |
| DOIs | |
| State | Published - Jul 6 2000 |
| Externally published | Yes |
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Keywords
- Alzheimer disease
- Antioxidants
- Free radicals
- Oxidative stress
ASJC Scopus subject areas
- Clinical Psychology
- Gerontology
- Geriatrics and Gerontology
- Psychiatry and Mental health
Cite this
Oxidative stress, antioxidants, and Alzheimer disease. / Rottkamp, Catherine; Nunomura, Akihiko; Raina, Arun K.; Sayre, Lawrence M.; Perry, George; Smith, Mark A.
In: Alzheimer Disease and Associated Disorders, Vol. 14, No. SUPPL. 1, 06.07.2000.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Oxidative stress, antioxidants, and Alzheimer disease
AU - Rottkamp, Catherine
AU - Nunomura, Akihiko
AU - Raina, Arun K.
AU - Sayre, Lawrence M.
AU - Perry, George
AU - Smith, Mark A.
PY - 2000/7/6
Y1 - 2000/7/6
N2 - Recent evidence in the field of Alzheimer disease research has highlighted the importance of oxidative processes in its pathogenesis. Examination of cellular changes shows that oxidative stress is an event that precedes the appearance of neurofibrillary tangles, one of the hallmark pathologies of the disease. Although it is still unclear what the initial source of the oxidative stress is in Alzheimer disease, it is likely that the process is highly dependent on the presence of redox-active transition metals, such as iron and copper. Because of the proximal role that oxidative stress mechanisms seem to play in the pathogenesis of Alzheimer disease, further investigation in this realm may lead to novel therapeutic strategies.
AB - Recent evidence in the field of Alzheimer disease research has highlighted the importance of oxidative processes in its pathogenesis. Examination of cellular changes shows that oxidative stress is an event that precedes the appearance of neurofibrillary tangles, one of the hallmark pathologies of the disease. Although it is still unclear what the initial source of the oxidative stress is in Alzheimer disease, it is likely that the process is highly dependent on the presence of redox-active transition metals, such as iron and copper. Because of the proximal role that oxidative stress mechanisms seem to play in the pathogenesis of Alzheimer disease, further investigation in this realm may lead to novel therapeutic strategies.
KW - Alzheimer disease
KW - Antioxidants
KW - Free radicals
KW - Oxidative stress
UR - http://www.scopus.com/inward/record.url?scp=0034050020&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034050020&partnerID=8YFLogxK
U2 - 10.1097/00002093-200000001-00010
DO - 10.1097/00002093-200000001-00010
M3 - Article
C2 - 10850732
AN - SCOPUS:0034050020
VL - 14
JO - Alzheimer Disease and Associated Disorders
JF - Alzheimer Disease and Associated Disorders
SN - 0893-0341
IS - SUPPL. 1
ER -