Oxidative Stress and Skin Fibrosis

Anjali Shroff, Andrew Mamalis, Jared Jagdeo

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations

Abstract

Fibrosis is defined as increased fibroblast proliferation and deposition of extracellular matrix components with potential clinical ramifications including organ dysfunction and failure. Fibrosis is a characteristic finding of various skin diseases which can have life-threatening consequences. These implications call for research into this topic as only a few treatments targeting fibrosis are available. In this review, we discuss oxidative stress and its role in skin fibrosis. Recent studies have implicated the importance of oxidative stress in a variety of cellular pathways directly and indirectly involved in the pathogenesis of skin fibrosis. The cellular pathways by which oxidative stress affects specific fibrotic skin disorders are also reviewed. Finally, we also describe various therapeutic approaches specifically targeting oxidative stress to prevent skin fibrosis. We believe oxidative stress is a relevant target, and understanding the role of oxidative stress in skin fibrosis will enhance knowledge of fibrotic skin diseases and potentially produce targeted therapeutic options.

Original languageEnglish (US)
Pages (from-to)257-267
Number of pages11
JournalCurrent Pathobiology Reports
Volume2
Issue number4
DOIs
StatePublished - Dec 1 2014

Keywords

  • Free radicals
  • Oxidative stress
  • Scars
  • Skin fibrosis
  • Skin scarring
  • Therapy

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Pathology and Forensic Medicine
  • Cancer Research

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