TY - JOUR
T1 - Oxidative strees, inflammation, and diabetic vasculopathies
T2 - The role of alpha tocopherol therapy
AU - Jialal, I.
AU - Venugopal, S. K.
PY - 2002/12/1
Y1 - 2002/12/1
N2 - The diabetic state confers an increased propensity to accelerated atherogenesis. In addition to the established risk factors, there is evidence for increased oxidative stress and inflammation in diabetes. Increased oxidative stress is manifested by increased lipid peroxidation (e.g. increased F2-isoprostanes) and increased DNA damage. Evidence for increased inflammation includes increased monocyte superoxide and pro-inflammatory cytokine release (IL-1, IL-6, and TNF-α), increased monocyte adhesion to endothelium and increased levels of plasma C-reactive protein, the prototypic marker of inflammation. Most importantly, alpha tocopherol therapy, especially at high doses, clearly shows a benefit with regards to LDL oxidation, isoprostanes and a decrease in inflammatory markers such as C-reactive protein, pro-inflammatory cytokines and PAI-1 levels. Thus, it appears that, in diabetes, alpha tocopherol therapy could emerge as an additional therapeutic modality.
AB - The diabetic state confers an increased propensity to accelerated atherogenesis. In addition to the established risk factors, there is evidence for increased oxidative stress and inflammation in diabetes. Increased oxidative stress is manifested by increased lipid peroxidation (e.g. increased F2-isoprostanes) and increased DNA damage. Evidence for increased inflammation includes increased monocyte superoxide and pro-inflammatory cytokine release (IL-1, IL-6, and TNF-α), increased monocyte adhesion to endothelium and increased levels of plasma C-reactive protein, the prototypic marker of inflammation. Most importantly, alpha tocopherol therapy, especially at high doses, clearly shows a benefit with regards to LDL oxidation, isoprostanes and a decrease in inflammatory markers such as C-reactive protein, pro-inflammatory cytokines and PAI-1 levels. Thus, it appears that, in diabetes, alpha tocopherol therapy could emerge as an additional therapeutic modality.
KW - Alpha tocopherol
KW - Antioxidant
KW - Atherosclerosis
KW - Diabetes
KW - Inflammation
KW - Oxidation stress
UR - http://www.scopus.com/inward/record.url?scp=0036902972&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036902972&partnerID=8YFLogxK
U2 - 10.1080/1071576021000038531
DO - 10.1080/1071576021000038531
M3 - Article
C2 - 12607825
AN - SCOPUS:0036902972
VL - 36
SP - 1331
EP - 1336
JO - Free Radical Research
JF - Free Radical Research
SN - 1071-5762
IS - 12
ER -