Oxidative strees, inflammation, and diabetic vasculopathies: The role of alpha tocopherol therapy

I. Jialal, S. K. Venugopal

Research output: Contribution to journalArticlepeer-review

109 Scopus citations

Abstract

The diabetic state confers an increased propensity to accelerated atherogenesis. In addition to the established risk factors, there is evidence for increased oxidative stress and inflammation in diabetes. Increased oxidative stress is manifested by increased lipid peroxidation (e.g. increased F2-isoprostanes) and increased DNA damage. Evidence for increased inflammation includes increased monocyte superoxide and pro-inflammatory cytokine release (IL-1, IL-6, and TNF-α), increased monocyte adhesion to endothelium and increased levels of plasma C-reactive protein, the prototypic marker of inflammation. Most importantly, alpha tocopherol therapy, especially at high doses, clearly shows a benefit with regards to LDL oxidation, isoprostanes and a decrease in inflammatory markers such as C-reactive protein, pro-inflammatory cytokines and PAI-1 levels. Thus, it appears that, in diabetes, alpha tocopherol therapy could emerge as an additional therapeutic modality.

Original languageEnglish (US)
Pages (from-to)1331-1336
Number of pages6
JournalFree Radical Research
Volume36
Issue number12
DOIs
StatePublished - Dec 1 2002

Keywords

  • Alpha tocopherol
  • Antioxidant
  • Atherosclerosis
  • Diabetes
  • Inflammation
  • Oxidation stress

ASJC Scopus subject areas

  • Biochemistry

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