Oxidative damage to plasma constituents by ozone

Carroll E Cross, Paul A. Motchnik, Bernd A. Bruener, Daniel A. Jones, Harparkash Kaur, Bruce N. Ames, Barry Halliwell

Research output: Contribution to journalArticlepeer-review

81 Scopus citations


The reaction of ozone (O3) with human blood plasma was studied to help understand possible events that could occur in the respiratory tract. Uric acid (quantitatively the most important scavenger) and ascorbic acid were oxidized quickly, protein-SH groups were lost more slowly, and there was no loss of bilirubin or α-tocopherol. There was little formation of lipid hydroperoxides and no detectable formation of 4-hydroxynonenal, hexanal or nonanal, or changes in lipoprotein electrophoretic mobility. Uric acid in human upper airway secretions may play a significant role in removing inhaled O3. Oxidative damage to lipids must not be assumed to be the key mechanism of respiratory tract O3 toxicity.

Original languageEnglish (US)
Pages (from-to)269-272
Number of pages4
JournalFEBS Letters
Issue number2-3
StatePublished - Feb 24 1992


  • Lipid peroxidation
  • Ozone
  • Protein damage
  • Uric acid: Oxidative damage

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology


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