Oxidative damage by ozone and nitrogen dioxide

synergistic toxicity in vivo but no evidence of synergistic oxidative damage in an extracellular fluid.

C. A. O'Neill, A. van der Vliet, J. P. Eiserich, Jerold A Last, B. Halliwell, Carroll E Cross

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Inhalation of ozone (O3) and/or nitrogen dioxide (.NO2) is associated with the development of inflammation in the respiratory tract and various alterations in pulmonary functions. Respiratory tract lining fluids (RTLFs) represent the first biological fluids coming into contact with these inhaled toxicants. Using plasma as a surrogate for RTLFs, we have previously shown that O3 [Cross, Motchnik, Bruener, Jones, Kaur, Ames and Halliwell (1992) FEBS Lett. 298, 269-272] and .NO2 [Halliwell, Hu, Louie, Duvall, Tarkington, Motchnik and Cross (1992) FEBS Lett. 313, 62-66] are both capable of depleting antioxidants and damaging proteins and lipids. O3 particularly damages proteins, whereas .NO2 induces the peroxidation of lipids and nitrates aromatic amino acids. It has been reported that O3 and .NO2 cause synergistic toxicity in rodents [Gielzleichter, Witschi and Last (1992) Tox. Appl. Pharmacol. 116, 1-9]. In the present chapter, we review evidence showing that combined exposure of these two oxidant gases to human plasma fails to exert synergistic oxidative damage to plasma constituents, and in fact, O3 and .NO2 antagonize each other's actions. We conclude that the potentiating effect of these two gases on morbidity and mortality in rodents represents a complex interactive biological effect rather than a simple synergistic oxidative effect in extracellular fluids.

Original languageEnglish (US)
Pages (from-to)139-152
Number of pages14
JournalBiochemical Society Symposium
Volume61
StatePublished - 1995

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Nitrogen Dioxide
Ozone
Extracellular Fluid
Respiratory System
Toxicity
Fluids
Rodentia
Gases
Linings
Aromatic Amino Acids
Plasma (human)
Lipids
Plasmas
Oxidants
Nitrates
Inhalation
Lipid Peroxidation
Proteins
Antioxidants
Contacts (fluid mechanics)

ASJC Scopus subject areas

  • Biochemistry

Cite this

Oxidative damage by ozone and nitrogen dioxide : synergistic toxicity in vivo but no evidence of synergistic oxidative damage in an extracellular fluid. / O'Neill, C. A.; van der Vliet, A.; Eiserich, J. P.; Last, Jerold A; Halliwell, B.; Cross, Carroll E.

In: Biochemical Society Symposium, Vol. 61, 1995, p. 139-152.

Research output: Contribution to journalArticle

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