Overview of monitoring of cerebral blood flow and metabolism after severe head injury

Jan Paul Muizelaar, M. L. Schroder

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

The relationships between cerebral blood flow (CBF), cerebral metabolism (cerebral metabolic rate of oxygen, CMRO2) and cerebral oxygen extraction (arteriovenous difference of oxygen, AVDO2) are discussed, using the formula CMRO2 = CBF x AVDO2. Metabolic autoregulation, pressure autoregulation and viscosity autoregulation can all be explained by the strong tendency of the brain to keep AVDO2 constant. Monitoring of CBF, CMRO2 or AVDO2 very early after injury is impractical, but the available data indicate that cerebral ischemia plays a considerable role at this stage. It can best be avoided by not 'treating' arterial hypertension and not using too much hyperventilation, while generous use of mannitol is probably beneficial. Once in the ICU, treatment can most practically be guided by monitoring of jugular bulb venous oxygen saturation. If saturation drops below 50%, the reason for this must be found (high intracranial pressure, blood pressure not high enough, too vigorous hyperventilation, arterial hypoxia, anemia) and must be treated accordingly.

Original languageEnglish (US)
JournalCanadian Journal of Neurological Sciences
Volume21
Issue numberSUPPL. 1
StatePublished - 1994
Externally publishedYes

Fingerprint

Cerebrovascular Circulation
Craniocerebral Trauma
Oxygen
Homeostasis
Hyperventilation
Hypertension
Intracranial Pressure
Mannitol
Brain Ischemia
Viscosity
Anemia
Neck
Pressure
Wounds and Injuries
Brain

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Overview of monitoring of cerebral blood flow and metabolism after severe head injury. / Muizelaar, Jan Paul; Schroder, M. L.

In: Canadian Journal of Neurological Sciences, Vol. 21, No. SUPPL. 1, 1994.

Research output: Contribution to journalArticle

@article{9adba8197c86453398b1951c6a3a5d06,
title = "Overview of monitoring of cerebral blood flow and metabolism after severe head injury",
abstract = "The relationships between cerebral blood flow (CBF), cerebral metabolism (cerebral metabolic rate of oxygen, CMRO2) and cerebral oxygen extraction (arteriovenous difference of oxygen, AVDO2) are discussed, using the formula CMRO2 = CBF x AVDO2. Metabolic autoregulation, pressure autoregulation and viscosity autoregulation can all be explained by the strong tendency of the brain to keep AVDO2 constant. Monitoring of CBF, CMRO2 or AVDO2 very early after injury is impractical, but the available data indicate that cerebral ischemia plays a considerable role at this stage. It can best be avoided by not 'treating' arterial hypertension and not using too much hyperventilation, while generous use of mannitol is probably beneficial. Once in the ICU, treatment can most practically be guided by monitoring of jugular bulb venous oxygen saturation. If saturation drops below 50{\%}, the reason for this must be found (high intracranial pressure, blood pressure not high enough, too vigorous hyperventilation, arterial hypoxia, anemia) and must be treated accordingly.",
author = "Muizelaar, {Jan Paul} and Schroder, {M. L.}",
year = "1994",
language = "English (US)",
volume = "21",
journal = "Canadian Journal of Neurological Sciences",
issn = "0317-1671",
publisher = "Canadian Journal of Neurological Sciences",
number = "SUPPL. 1",

}

TY - JOUR

T1 - Overview of monitoring of cerebral blood flow and metabolism after severe head injury

AU - Muizelaar, Jan Paul

AU - Schroder, M. L.

PY - 1994

Y1 - 1994

N2 - The relationships between cerebral blood flow (CBF), cerebral metabolism (cerebral metabolic rate of oxygen, CMRO2) and cerebral oxygen extraction (arteriovenous difference of oxygen, AVDO2) are discussed, using the formula CMRO2 = CBF x AVDO2. Metabolic autoregulation, pressure autoregulation and viscosity autoregulation can all be explained by the strong tendency of the brain to keep AVDO2 constant. Monitoring of CBF, CMRO2 or AVDO2 very early after injury is impractical, but the available data indicate that cerebral ischemia plays a considerable role at this stage. It can best be avoided by not 'treating' arterial hypertension and not using too much hyperventilation, while generous use of mannitol is probably beneficial. Once in the ICU, treatment can most practically be guided by monitoring of jugular bulb venous oxygen saturation. If saturation drops below 50%, the reason for this must be found (high intracranial pressure, blood pressure not high enough, too vigorous hyperventilation, arterial hypoxia, anemia) and must be treated accordingly.

AB - The relationships between cerebral blood flow (CBF), cerebral metabolism (cerebral metabolic rate of oxygen, CMRO2) and cerebral oxygen extraction (arteriovenous difference of oxygen, AVDO2) are discussed, using the formula CMRO2 = CBF x AVDO2. Metabolic autoregulation, pressure autoregulation and viscosity autoregulation can all be explained by the strong tendency of the brain to keep AVDO2 constant. Monitoring of CBF, CMRO2 or AVDO2 very early after injury is impractical, but the available data indicate that cerebral ischemia plays a considerable role at this stage. It can best be avoided by not 'treating' arterial hypertension and not using too much hyperventilation, while generous use of mannitol is probably beneficial. Once in the ICU, treatment can most practically be guided by monitoring of jugular bulb venous oxygen saturation. If saturation drops below 50%, the reason for this must be found (high intracranial pressure, blood pressure not high enough, too vigorous hyperventilation, arterial hypoxia, anemia) and must be treated accordingly.

UR - http://www.scopus.com/inward/record.url?scp=0028337655&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028337655&partnerID=8YFLogxK

M3 - Article

C2 - 8087732

AN - SCOPUS:0028337655

VL - 21

JO - Canadian Journal of Neurological Sciences

JF - Canadian Journal of Neurological Sciences

SN - 0317-1671

IS - SUPPL. 1

ER -