"Overshoot" of O2 is required to maintain baseline tissue oxygenation at locations distal to blood vessels

Anna Devor, Sava Sakadžić, Payam A. Saisan, Mohammad A. Yaseen, Emmanuel Roussakis, Vivek Srinivasan, Sergei A. Vinogradov, Bruce R. Rosen, Richard B. Buxton, Anders M. Dale, David A. Boas

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Abstract

In vivo imaging of cerebral tissue oxygenation is important in defining healthy physiology and pathological departures associated with cerebral disease. We used a recently developed two-photon microscopy method, based on a novel phosphorescent nanoprobe, to image tissue oxygenation in the rat primary sensory cortex in response to sensory stimulation. Our measurements showed that a stimulusevoked increase in tissue pO2 depended on the baseline pO2 level. In particular, during sustained stimulation, the steady-state pO2 at low-baseline locations remained at the baseline, despite large pO2 increases elsewhere. In contrast to the steady state, where pO2 never decreased below the baseline, transient decreases occurred during the "initial dip" and "poststimulus undershoot." These results suggest that the increase in blood oxygenation during the hemodynamic response, which has been perceived as a paradox, may serve to prevent a sustained oxygenation drop at tissue locations that are remote from the vascular feeding sources.

Original languageEnglish (US)
Pages (from-to)13676-13681
Number of pages6
JournalJournal of Neuroscience
Volume31
Issue number38
DOIs
StatePublished - Sep 21 2011
Externally publishedYes

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ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)

Cite this

Devor, A., Sakadžić, S., Saisan, P. A., Yaseen, M. A., Roussakis, E., Srinivasan, V., Vinogradov, S. A., Rosen, B. R., Buxton, R. B., Dale, A. M., & Boas, D. A. (2011). "Overshoot" of O2 is required to maintain baseline tissue oxygenation at locations distal to blood vessels. Journal of Neuroscience, 31(38), 13676-13681. https://doi.org/10.1523/JNEUROSCI.1968-11.2011